Top 100 US Patents in Genetic Engineering
section c - chemistry; metallurgy > biochemistry; beer; spirits; wine; vinegar; microbiology; enzymology; mutation or genetic engineering > micro-organisms or enzymes; compositions thereof; propagating, preserving, or maintaining micro-organisms; mutation or genetic engineering; culture media
Sorted by IPQ® Score, an objective measure of patent quality. View scores and methodology at PatentRatings.com. You can also view all by publication date instead.
US4588585 (A), filed
Sep 28, 1984
, published
May 13, 1986
- CETUS CORP
Muteins of biologically active proteins such as IFN- beta and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect...
US6720166 (B2), filed
Jun 05, 1995
, published
Apr 13, 2004
- ABBOTT LAB
Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to...
US7271250 (B2), filed
Jun 27, 2002
, published
Sep 18, 2007
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US6197563 (B1), filed
Nov 18, 1994
, published
Mar 06, 2001
- ROCHE MOLECULAR SYSTEMS INC
The present invention is directed to a process for amplifying any target nucleic acid sequence contained in a nucleic acid or mixture thereof using a thermostable enzyme. The process comprises treating separate complementary strands of the nucleic acid with a...
US4775624 (A), filed
Feb 08, 1985
, published
Oct 04, 1988
- LILLY CO ELI
The present invention comprises novel DNA compounds which encode human protein C activity. A variety of eukaryotic and prokaryotic recombinant DNA expression vectors have been constructed that comprise the novel protein C activity-encoding DNA and drive...
US6417429 (B1), filed
Nov 25, 1998
, published
Jul 09, 2002
- SCRIPPS RESEARCH INST
The present invention relates to expression and assembly of foreign multimeric proteins-e.g., antibodies-in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional...
US6350866 (B1), filed
Dec 08, 1997
, published
Feb 26, 2002
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding FtsZ of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US6268175 (B1), filed
Dec 08, 1997
, published
Jul 31, 2001
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding gcp of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US6071724 (A), filed
Dec 08, 1997
, published
Jun 06, 2000
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding Era of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US6528706 (B1), filed
Aug 21, 2001
, published
Mar 04, 2003
- MASSACHUSETTS INST TECHNOLOGY
A method for controlling and modifying biopolymer synthesis by manipulation of the genetics and enzymology of synthesis of polyhydroxybutyrate (PHB) and polyhydroxyalkanoate (PHA) polyesters at the molecular level in procaryotic and eukaryotic cells,...
US6702705 (B1), filed
Feb 22, 1995
, published
Mar 09, 2004
- IGEN INT INC
Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.
US4259477 (A), filed
Jun 04, 1979
, published
Mar 31, 1981
- MERCK CO INC
Cellulase in xanthan gum can be completely destroyed by treating xanthan gum beer with about 0.08 to 0.1% alkali metal hypochlorite followed by heat treatment.
US5569812 (A), filed
Jun 02, 1995
, published
Oct 29, 1996
- ANTICANCER INC
A nude mouse model for human neoplastic disease having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the tissue is obtained.
US6919439 (B2), filed
May 23, 2002
, published
Jul 19, 2005
- ISIS PHARMACEUTICALS INC
Linked nucleosides having at least one functionalized nucleosid that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitamin, lipid soluble...
US5837500 (A), filed
Apr 03, 1995
, published
Nov 17, 1998
- DYAX CORP
In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a...
US6780613 (B1), filed
Jun 07, 1995
, published
Aug 24, 2004
- GENENTECH INC
The invention provides methods for the systematic analysis of the structure and function of polypeptides by identifying active domains which influence the activity of the polypeptide with a target substance. Such active domains are determined by substituting...
US7029873 (B2), filed
Nov 20, 2001
, published
Apr 18, 2006
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US5059341 (A), filed
Apr 02, 1990
, published
Oct 22, 1991
- OLIN CORP
This invention is directed to a detergent composition comprising the microbial lipase SD2, dodecylbenzene sulfonate, and gelatin. In the detergent composition, the lipase SD2 is characterized by having (i) optimum pH for washing activity of about 8+/-0.5; (ii)...
US7179893 (B2), filed
Apr 07, 2006
, published
Feb 20, 2007
- CENTOCOR INC
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...
US4683202 (A), filed
Oct 25, 1985
, published
Jul 28, 1987
- CETUS CORP
US7223838 (B2), filed
May 03, 2002
, published
May 29, 2007
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US6458527 (B1), filed
Jun 28, 1993
, published
Oct 01, 2002
- CHIRON CORP
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to...
US5605662 (A), filed
Nov 01, 1993
, published
Feb 25, 1997
- NANOGEN INC
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization,...
US6627395 (B1), filed
Jun 06, 1995
, published
Sep 30, 2003
- US HEALTH
The identification, separation, purification, and propagation of the HIV-1 virus is provided. Moreover, the preparation of antigens from HIV-1 is further provided. The identification of HIV-1 involves the purification of a virus sample from lymphocytes and...
US6919186 (B2), filed
Sep 28, 2001
, published
Jul 19, 2005
- AMERSHAM PLC
The present invention provides novel engineered derivatives of green fluorescent protein (GFP) which have an amino acid sequence which is modified by amino acid substitution compared with the amino acid sequence of wild type Green Fluorescent Protein. The...
US6833132 (B1), filed
May 31, 1995
, published
Dec 21, 2004
- US HEALTH
Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various...
US6127155 (A), filed
Apr 24, 1992
, published
Oct 03, 2000
- ROCHE MOLECULAR SYSTEMS INC
A purified thermostable nucleic acid polymerase is obtained that has unique characteristics. Preferably the nucleic acid polymerase is DNA polymerase isolated from a Thermus aquaticus species and has a molecular weight of about 86,000-95,000 daltons. The...
US6309635 (B1), filed
Nov 28, 1994
, published
Oct 30, 2001
- MASSACHUSETTS INST TECHNOLOGY
A method is provided whereby cells having a desired function are seeded on and into biocompatible, biodegradable or non-degradable porous polymer scaffolding matrix, previously implanted in a patient and infiltrated with blood vessels and connective tissue, to...
US4945050 (A), filed
Nov 13, 1984
, published
Jul 31, 1990
- CORNELL RES FOUNDATION INC
Inert or biologically active particles are propelled at cells at a speed whereby the particles penetrate the surface of the cells and become incorporated into the interior of the cells. The process can be used to mark cells or tissue or to biochemically affect...
US5621090 (A), filed
Jun 26, 1992
, published
Apr 15, 1997
- UNIV PRINCETON
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid...
US5700778 (A), filed
Jun 02, 1995
, published
Dec 23, 1997
- SALK INST FOR BIOLOGICAL STUDI
Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion...
US7150870 (B2), filed
Sep 04, 2003
, published
Dec 19, 2006
- COMBI CO
The invention prevents or treats a tumor, inhibiting tumor growth and malignant progression by providing an antitumor agent containing a treated SOD as the active ingredient, especially a melon SOD coated with gliadin. The invention also applies to a method of...
US6846676 (B2), filed
Jun 08, 1999
, published
Jan 25, 2005
- TRANSKARYOTIC THERAPIES INC
The invention provides primary and secondary cells that are transfected with a nucleic acid molecule that encodes erythropoietin, clonal or heterogenous strains of such cells, and methods of producing these cell strains.
US5750657 (A), filed
Oct 18, 1993
, published
May 12, 1998
- SQUIBB BRISTOL MYERS CO
The subject invention relates to methods and compositions using nondynamic fibrin monomer which is selectively converted to a fibrin polymer which serves as the fibrin sealant.
US6884616 (B1), filed
Apr 27, 2000
, published
Apr 26, 2005
- ZLB BEHRING GMBH
A DNA-construct has been disclosed which is suitable for a tissue-specific expression of a blood coagulation factor like Factor IX, which comprises a DNA coding for an amino acid sequence of a blood coagulation factor and a DNA coding for a promoter which is...
US6060282 (A), filed
Dec 08, 1997
, published
May 09, 2000
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding dpj of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US4603112 (A), filed
Dec 08, 1982
, published
Jul 29, 1986
- HEALTH RESEARCH INC
What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified...
US4859609 (A), filed
Apr 30, 1986
, published
Aug 22, 1989
- GENENTECH INC
US6090573 (A), filed
Mar 03, 1999
, published
Jul 18, 2000
A method is presented for detecting eubacteria and fungus in biological samples, and, if present, determining their antibiotic sensitivity, where the presence and amount of eubacteria or fungus is measured by means of catalytically inactive murein binding...
US6531585 (B1), filed
Feb 01, 1991
, published
Mar 11, 2003
- PASTEUR INSTITUT
A previously isolated hepatitis B virus (HBV) integration in a 147 bp cellular DNA fragment linked to hepatocellular carcinoma (HCC) was used as a probe to clone the corresponding complementary DNA from a human liver cDNA library. Nucleotide sequence analysis...
US5098833 (A), filed
Feb 23, 1989
, published
Mar 24, 1992
- GENENTECH INC
DNA isolates coding for a lymphocyte homing receptor and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the lymphocyte homing receptor useful in therapeutic or diagnostic compositions.
US4299916 (A), filed
Dec 26, 1979
, published
Nov 10, 1981
- SYVA CO
An assay method and compositions are provided for determining the presence of an analyte in a sample. The analyte is a member of an immunological pair (mip) of immunogens-ligand and receptor. The method has two basic elements: a solid surface to which one of...
US7189534 (B2), filed
May 21, 2002
, published
Mar 13, 2007
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US6339071 (B1), filed
Jan 20, 2000
, published
Jan 15, 2002
- ANGIOGENE INC
The present invention relates to antisense oligonucleotides directed to the human cyclin E gene for inhibiting its expression, and to a method for inhibiting cellular proliferation. The antisense oligonucleotides of the present invention have been designed...
US4271145 (A), filed
Oct 22, 1979
, published
Jun 02, 1981
- MASSACHUSETTS GEN HOSPITAL
Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be...
US6270989 (B1), filed
Mar 17, 1995
, published
Aug 07, 2001
- TRANSKARYOTIC THERAPIES INC
The invention relates to novel human DNA sequences, targeting constructs, and methods for producing novel genes encoding thrombopoietin, DNase I, and beta-interferon by homologous recombination. The targeting constructs comprise at least: a) a targeting...
US6261835 (B1), filed
Jan 20, 1995
, published
Jul 17, 2001
- STRYKER CORP
Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural...
US5952462 (A), filed
Nov 02, 1994
, published
Sep 14, 1999
- IGEN INT INC
Antigens capable of eliciting antibodies which can catalyze chemical reactions, in particular, the cleavage or formation of a peptide linkage, comprising a hapten or a hapten and a suitable carrier molecule are disclosed. Haptens include, among others, silicon...
US6117679 (A), filed
Mar 25, 1996
, published
Sep 12, 2000
- MAXYGEN INC
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides...
US6927051 (B1), filed
Apr 04, 2002
, published
Aug 09, 2005
- UNIV AKRON
An enzymatic chemical process comprising the steps of providing a biphasic liquid medium that includes one polar phase and one nonpolar phase in contact with each other, wherein at least one of the phases includes reactants, and adding a polymer-protein...
US4795699 (A), filed
Jan 14, 1987
, published
Jan 03, 1989
- HARVARD COLLEGE
This invention relates to T7-type DNA polymerases and method for using them.
US6803499 (B1), filed
May 07, 1997
, published
Oct 12, 2004
- DEKALB GENETICS CORP
This invention relates to a reproducible system for the production of stable, genetically transformed maize cells, and to methods of selecting cells that have been transformed. One method of selection disclosed employs the Streptomyces bar gene introduced by...
US6004929 (A), filed
Mar 29, 1995
, published
Dec 21, 1999
- ZYMOGENETICS INC
Dimeric proteins having substantially the same biological activity as PDGF are disclosed. More specifically, the protein may have two substantially identical polypeptide chains, each of the chains being substantially homologous to the A-chain of PDGF....
US7063829 (B2), filed
Nov 06, 2002
, published
Jun 20, 2006
- INSTITU CURIE
The invention concerns peptide fragments of the WASP family proteins, or peptides derived from said fragments, and their uses in particular for preparing reagents for use in implementing a method for detecting or screening molecules with inhibiting or...
US6916648 (B2), filed
Oct 24, 2001
, published
Jul 12, 2005
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US7227005 (B1), filed
Feb 25, 1999
, published
Jun 05, 2007
- HUMAN GENOME SCIENCES INC
Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by...
US7291329 (B2), filed
Apr 15, 2002
, published
Nov 06, 2007
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US6204020 (B1), filed
Mar 09, 1995
, published
Mar 20, 2001
- CHIRON CORP
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant...
US5723323 (A), filed
Dec 02, 1994
, published
Mar 03, 1998
The present invention is directed to a process for the production of a peptide, polypeptide, or protein having a predetermined property. In accordance with one embodiment, the process begins by producing by way of synthetic polynucleotide coupling, stochastica...
US4888281 (A), filed
Nov 27, 1984
, published
Dec 19, 1989
- IGEN INC
A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal antibody under conditions permitting the formation of a complex...
US7172864 (B1), filed
Jan 24, 2000
, published
Feb 06, 2007
- NANOGEN
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations,...
US4766073 (A), filed
Aug 13, 1986
, published
Aug 23, 1988
- ZYMOGENETICS INC
Methods for expressing a variety of biologically active PDGF analogs in eucaryotic cells are disclosed. The methods generally comprise introducing into a eucaryotic host cell a DNA construct capable of directing the expression and secretion of biologically...
US6780982 (B2), filed
Feb 06, 2001
, published
Aug 24, 2004
- THIRD WAVE TECH INC
The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags...
US6806359 (B1), filed
Jun 05, 1995
, published
Oct 19, 2004
- SALK INST FOR BIOLOGICAL STUDI
The present invention provides substantially pure DNA's comprised of sequences which encode proteins having the hormone-binding and/or transcription-activating characteristics of a glucocorticoid receptor, a mineralocorticoid receptor, or a thyroid hormone...
US6929947 (B2), filed
Aug 31, 2001
, published
Aug 16, 2005
- GENENTECH INC
The present invention is directed to nucleic acids encoding a secreted polypeptide that inhibits neoplastic growth in tumor cells. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules...
US6100042 (A), filed
Oct 13, 1994
, published
Aug 08, 2000
- CADUS PHARMACEUTICAL CORP
Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of alpha -factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a...
US6497872 (B1), filed
Jun 07, 1995
, published
Dec 24, 2002
- NEUROSPHERES HOLDINGS LTD
The invention provides methods of transplanting multipotent neural stem cell progeny to a host by obtaining a population of cells derived from mammalian neural tissue containing at least one multipotent CNS multipotent neural stem cell; culturing the neural...
US4981784 (A), filed
Nov 30, 1988
, published
Jan 01, 1991
- SALK INST FOR BIOLOGICAL STUDI
US5910580 (A), filed
Dec 08, 1997
, published
Jun 08, 1999
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding HI1648 of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US6271000 (B1), filed
Dec 08, 1997
, published
Aug 07, 2001
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding enzyme mraY of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded enzyme, and a method for identifying compounds that inhibit said enzyme.
US4375414 (A), filed
Jan 21, 1977
, published
Mar 01, 1983
- STRAHILEVITZ MEIR
Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these drugs. These methods are based upon treating the psychoactive...
US6732573 (B2), filed
Apr 22, 2002
, published
May 11, 2004
- RHEOLOGICS INC
An apparatus and method for determining the viscosity of the circulating blood of a living being over plural shear rates caused by a decreasing pressure differential by monitoring the changing weight of the blood, or the changing level of a column of blood...
US5814469 (A), filed
Jun 07, 1995
, published
Sep 29, 1998
- CHIRON CORP
Methods are disclosed for diagnosing diseases resulting from undesirable cell adhesion of IL-1 receptor positive cells to biological materials, particular to endothelial cells, or autoimmune related diseases, preferably graft versus host disease, or IL-1...
US5824549 (A), filed
Jun 02, 1995
, published
Oct 20, 1998
- CHIRON CORP
Medicaments and methods of using the same are disclosed for treating or preventing diseases resulting from undesirable cell adhesion of IL-1 receptor positive cells to biological materials, particular to endothelial cells, or autoimmune related diseases,...
US6692917 (B2), filed
Aug 27, 2001
, published
Feb 17, 2004
- THIRD WAVE TECH INC
The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on...
US5200333 (A), filed
Mar 19, 1991
, published
Apr 06, 1993
- NEW ENGLAND BIOLABS INC
Methods for cloning restriction enzymes and their corresponding modification enzymes by selecting clones resistant to digestion by the restriction enzyme and subsequent selection of clones containing the restriction gene.
US6730778 (B2), filed
Jun 09, 1999
, published
May 04, 2004
- UPJOHN CO
The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The...
US5958730 (A), filed
Dec 08, 1997
, published
Sep 28, 1999
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding FtsY of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US4642411 (A), filed
Feb 21, 1985
, published
Feb 10, 1987
- MOLECULAR GENETICS RES DEV
This invention is direction to the production of novel plant genotypes or lines which produce increased free tryptophan levels and are resistant to inhibition by analogs which normally inhibit the activity of the enzyme anthranilate synthase before alteration....
US6051226 (A), filed
Dec 30, 1993
, published
Apr 18, 2000
- INST OF VIROLOGY SLOVAK ACADEM
A new gene-MN-and proteins/polypeptides encoded therefrom are disclosed. Recombinant nucleic acid molecules for expressing MN proteins/polypeptides and fusion proteins are provided. Expression of the MN gene is disclosed as being associated with tumorigenicity...
US6429186 (B1), filed
Sep 19, 1994
, published
Aug 06, 2002
- GENENTECH INC
We have discovered that growth hormones form ternary complexes with their receptors in which site 1 on the hormone first binds to one molecule of receptor and then hormone site 2 then binds to another molecule of receptor, thereby producing a 1:2 complex. We...
US6312679 (B1), filed
Mar 24, 1993
, published
Nov 06, 2001
- DOW CHEMICAL CO
Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the...
US4801542 (A), filed
Feb 25, 1985
, published
Jan 31, 1989
- ZYMOGENETICS INC
US5583016 (A), filed
Oct 27, 1994
, published
Dec 10, 1996
- GERON CORP
Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
US7074592 (B2), filed
Jul 18, 2001
, published
Jul 11, 2006
- GENETECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US5801154 (A), filed
Apr 08, 1997
, published
Sep 01, 1998
- ISIS PHARMACEUTICALS INC
Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP). In accordance with referred embodiments,...
US4581847 (A), filed
Sep 04, 1984
, published
Apr 15, 1986
- MOLECULAR GENETICS RES DEV
This invention is directed to the production of novel plant genotypes or lines which produce increased free tryptophan levels and are resistant to inhibition by analogs which normally inhibit the activity of the enzyme anthranilate synthase before alteration....
US6184027 (B1), filed
Mar 04, 1999
, published
Feb 06, 2001
- SUPERVISORS LOUISIANA STATE UN
Catalytically inactive murein binding enzyme diagnostic reagents and methods and kits for detecting eubacteria and fungus in biological samples.
US5677195 (A), filed
Nov 20, 1992
, published
Oct 14, 1997
- AFFYMAX TECH NV
A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the...
US5840496 (A), filed
Jun 02, 1995
, published
Nov 24, 1998
- CHIRON CORP
Medicaments and methods of using the same are disclosed for treating or preventing diseases resulting from undesirable cell adhesion of IL-1 receptor positive cells to biological materials, particular to endothelial cells, or autoimmune related diseases,...
US4361549 (A), filed
Apr 26, 1979
, published
Nov 30, 1982
- ORTHO PHARMA CORP
Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells and cutaneous T lymphoma cells. The hybrid is formed by fusing splenocytes from immunized CAF1 mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic...
US7078221 (B2), filed
Jan 03, 2001
, published
Jul 18, 2006
- STRYKER BIOTECH
Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural...
US7045289 (B2), filed
May 24, 2001
, published
May 16, 2006
- THIRD WAVE TECH INC
The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations...
US7456012 (B2), filed
Dec 02, 2003
, published
Nov 25, 2008
- CELLECTRICON AB
The invention provides hollow-tip-electrodes for spatially localized delivery of substances to one or more biological targets present in a population comprising target and non-target molecules, macromolecules, and/or cells. The invention also provides...
US5849870 (A), filed
Jun 05, 1995
, published
Dec 15, 1998
- NOVARTIS FINANCE CORP
The present invention is drawn to pesticidal strains and proteins. Bacillus strains which are capable of producing pesticidal proteins and auxiliary proteins during vegetative growth are provided. Also provided are the purified proteins, nucleotide sequences...
US7385033 (B2), filed
Jul 15, 2002
, published
Jun 10, 2008
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US6117674 (A), filed
Dec 29, 1994
, published
Sep 12, 2000
- NASA
A process for propagating a pathogen in a three-dimensional tissue mass cultured at microgravity conditions in a culture vessel containing culture media and a culture matrix is provided. The three-dimensional tissue mass is inoculated with a pathogen and...
US6852848 (B2), filed
Jul 16, 2001
, published
Feb 08, 2005
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US4894228 (A), filed
Jul 12, 1988
, published
Jan 16, 1990
- US HEALTH
The present invention provides an attenuated hepatitis A virus useful as a vaccine.
