Top 100 US Patents in Genetic Engineering
section c - chemistry; metallurgy > biochemistry; beer; spirits; wine; vinegar; microbiology; enzymology; mutation or genetic engineering > micro-organisms or enzymes; compositions thereof; propagating, preserving, or maintaining micro-organisms; mutation or genetic engineering; culture media
Sorted by IPQ® Score, an objective measure of patent quality. View scores and methodology at PatentRatings.com. You can also view all by publication date instead.
US4588585 (A), filed
Fri Sep 28 00:00:00 CDT 1984
, published
Tue May 13 00:00:00 CDT 1986
- CETUS CORP
Muteins of biologically active proteins such as IFN- beta and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect...
US6720166 (B2), filed
Mon Jun 05 00:00:00 CDT 1995
, published
Tue Apr 13 00:00:00 CDT 2004
- ABBOTT LAB
Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to...
US7271250 (B2), filed
Thu Jun 27 00:00:00 CDT 2002
, published
Tue Sep 18 00:00:00 CDT 2007
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US6197563 (B1), filed
Fri Nov 18 00:00:00 CST 1994
, published
Tue Mar 06 00:00:00 CST 2001
- ROCHE MOLECULAR SYSTEMS INC
The present invention is directed to a process for amplifying any target nucleic acid sequence contained in a nucleic acid or mixture thereof using a thermostable enzyme. The process comprises treating separate complementary strands of the nucleic acid with a...
US4775624 (A), filed
Fri Feb 08 00:00:00 CST 1985
, published
Tue Oct 04 00:00:00 CDT 1988
- LILLY CO ELI
The present invention comprises novel DNA compounds which encode human protein C activity. A variety of eukaryotic and prokaryotic recombinant DNA expression vectors have been constructed that comprise the novel protein C activity-encoding DNA and drive...
US6417429 (B1), filed
Wed Nov 25 00:00:00 CST 1998
, published
Tue Jul 09 00:00:00 CDT 2002
- SCRIPPS RESEARCH INST
The present invention relates to expression and assembly of foreign multimeric proteins-e.g., antibodies-in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional...
US6350866 (B1), filed
Mon Dec 08 00:00:00 CST 1997
, published
Tue Feb 26 00:00:00 CST 2002
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding FtsZ of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US6268175 (B1), filed
Mon Dec 08 00:00:00 CST 1997
, published
Tue Jul 31 00:00:00 CDT 2001
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding gcp of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US6071724 (A), filed
Mon Dec 08 00:00:00 CST 1997
, published
Tue Jun 06 00:00:00 CDT 2000
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding Era of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US6528706 (B1), filed
Tue Aug 21 00:00:00 CDT 2001
, published
Tue Mar 04 00:00:00 CST 2003
- MASSACHUSETTS INST TECHNOLOGY
A method for controlling and modifying biopolymer synthesis by manipulation of the genetics and enzymology of synthesis of polyhydroxybutyrate (PHB) and polyhydroxyalkanoate (PHA) polyesters at the molecular level in procaryotic and eukaryotic cells,...
US6702705 (B1), filed
Wed Feb 22 00:00:00 CST 1995
, published
Tue Mar 09 00:00:00 CST 2004
- IGEN INT INC
Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.
US4259477 (A), filed
Mon Jun 04 00:00:00 CDT 1979
, published
Tue Mar 31 00:00:00 CST 1981
- MERCK CO INC
Cellulase in xanthan gum can be completely destroyed by treating xanthan gum beer with about 0.08 to 0.1% alkali metal hypochlorite followed by heat treatment.
US5569812 (A), filed
Fri Jun 02 00:00:00 CDT 1995
, published
Tue Oct 29 00:00:00 CST 1996
- ANTICANCER INC
A nude mouse model for human neoplastic disease having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the tissue is obtained.
US6919439 (B2), filed
Thu May 23 00:00:00 CDT 2002
, published
Tue Jul 19 00:00:00 CDT 2005
- ISIS PHARMACEUTICALS INC
Linked nucleosides having at least one functionalized nucleosid that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitamin, lipid soluble...
US5837500 (A), filed
Mon Apr 03 00:00:00 CDT 1995
, published
Tue Nov 17 00:00:00 CST 1998
- DYAX CORP
In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a...
US6780613 (B1), filed
Wed Jun 07 00:00:00 CDT 1995
, published
Tue Aug 24 00:00:00 CDT 2004
- GENENTECH INC
The invention provides methods for the systematic analysis of the structure and function of polypeptides by identifying active domains which influence the activity of the polypeptide with a target substance. Such active domains are determined by substituting...
US7029873 (B2), filed
Tue Nov 20 00:00:00 CST 2001
, published
Tue Apr 18 00:00:00 CDT 2006
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US5059341 (A), filed
Mon Apr 02 00:00:00 CDT 1990
, published
Tue Oct 22 00:00:00 CDT 1991
- OLIN CORP
This invention is directed to a detergent composition comprising the microbial lipase SD2, dodecylbenzene sulfonate, and gelatin. In the detergent composition, the lipase SD2 is characterized by having (i) optimum pH for washing activity of about 8+/-0.5; (ii)...
US7179893 (B2), filed
Fri Apr 07 00:00:00 CDT 2006
, published
Tue Feb 20 00:00:00 CST 2007
- CENTOCOR INC
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...
US4683202 (A), filed
Fri Oct 25 00:00:00 CDT 1985
, published
Tue Jul 28 00:00:00 CDT 1987
- CETUS CORP
US4683202 (B1), filed
Fri Oct 25 00:00:00 CDT 1985
, published
Tue Nov 27 00:00:00 CST 1990
- CETUS CORP
US7223838 (B2), filed
Fri May 03 00:00:00 CDT 2002
, published
Tue May 29 00:00:00 CDT 2007
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US6458527 (B1), filed
Mon Jun 28 00:00:00 CDT 1993
, published
Tue Oct 01 00:00:00 CDT 2002
- CHIRON CORP
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to...
US5605662 (A), filed
Mon Nov 01 00:00:00 CST 1993
, published
Tue Feb 25 00:00:00 CST 1997
- NANOGEN INC
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization,...
US6627395 (B1), filed
Tue Jun 06 00:00:00 CDT 1995
, published
Tue Sep 30 00:00:00 CDT 2003
- US HEALTH
The identification, separation, purification, and propagation of the HIV-1 virus is provided. Moreover, the preparation of antigens from HIV-1 is further provided. The identification of HIV-1 involves the purification of a virus sample from lymphocytes and...
US6919186 (B2), filed
Fri Sep 28 00:00:00 CDT 2001
, published
Tue Jul 19 00:00:00 CDT 2005
- AMERSHAM PLC
The present invention provides novel engineered derivatives of green fluorescent protein (GFP) which have an amino acid sequence which is modified by amino acid substitution compared with the amino acid sequence of wild type Green Fluorescent Protein. The...
US6833132 (B1), filed
Wed May 31 00:00:00 CDT 1995
, published
Tue Dec 21 00:00:00 CST 2004
- US HEALTH
Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various...
US6127155 (A), filed
Fri Apr 24 00:00:00 CDT 1992
, published
Tue Oct 03 00:00:00 CDT 2000
- ROCHE MOLECULAR SYSTEMS INC
A purified thermostable nucleic acid polymerase is obtained that has unique characteristics. Preferably the nucleic acid polymerase is DNA polymerase isolated from a Thermus aquaticus species and has a molecular weight of about 86,000-95,000 daltons. The...
US6309635 (B1), filed
Mon Nov 28 00:00:00 CST 1994
, published
Tue Oct 30 00:00:00 CST 2001
- MASSACHUSETTS INST TECHNOLOGY
A method is provided whereby cells having a desired function are seeded on and into biocompatible, biodegradable or non-degradable porous polymer scaffolding matrix, previously implanted in a patient and infiltrated with blood vessels and connective tissue, to...
US4945050 (A), filed
Tue Nov 13 00:00:00 CST 1984
, published
Tue Jul 31 00:00:00 CDT 1990
- CORNELL RES FOUNDATION INC
Inert or biologically active particles are propelled at cells at a speed whereby the particles penetrate the surface of the cells and become incorporated into the interior of the cells. The process can be used to mark cells or tissue or to biochemically affect...
US5621090 (A), filed
Fri Jun 26 00:00:00 CDT 1992
, published
Tue Apr 15 00:00:00 CDT 1997
- UNIV PRINCETON
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid...
US5700778 (A), filed
Fri Jun 02 00:00:00 CDT 1995
, published
Tue Dec 23 00:00:00 CST 1997
- SALK INST FOR BIOLOGICAL STUDI
Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion...
US7150870 (B2), filed
Thu Sep 04 00:00:00 CDT 2003
, published
Tue Dec 19 00:00:00 CST 2006
- COMBI CO
The invention prevents or treats a tumor, inhibiting tumor growth and malignant progression by providing an antitumor agent containing a treated SOD as the active ingredient, especially a melon SOD coated with gliadin. The invention also applies to a method of...
US6846676 (B2), filed
Tue Jun 08 00:00:00 CDT 1999
, published
Tue Jan 25 00:00:00 CST 2005
- TRANSKARYOTIC THERAPIES INC
The invention provides primary and secondary cells that are transfected with a nucleic acid molecule that encodes erythropoietin, clonal or heterogenous strains of such cells, and methods of producing these cell strains.
US5750657 (A), filed
Mon Oct 18 00:00:00 CDT 1993
, published
Tue May 12 00:00:00 CDT 1998
- SQUIBB BRISTOL MYERS CO
The subject invention relates to methods and compositions using nondynamic fibrin monomer which is selectively converted to a fibrin polymer which serves as the fibrin sealant.
US6884616 (B1), filed
Thu Apr 27 00:00:00 CDT 2000
, published
Tue Apr 26 00:00:00 CDT 2005
- ZLB BEHRING GMBH
A DNA-construct has been disclosed which is suitable for a tissue-specific expression of a blood coagulation factor like Factor IX, which comprises a DNA coding for an amino acid sequence of a blood coagulation factor and a DNA coding for a promoter which is...
US6060282 (A), filed
Mon Dec 08 00:00:00 CST 1997
, published
Tue May 09 00:00:00 CDT 2000
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding dpj of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US4603112 (A), filed
Wed Dec 08 00:00:00 CST 1982
, published
Tue Jul 29 00:00:00 CDT 1986
- HEALTH RESEARCH INC
What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified...
US4859609 (A), filed
Wed Apr 30 00:00:00 CDT 1986
, published
Tue Aug 22 00:00:00 CDT 1989
- GENENTECH INC
US6090573 (A), filed
Wed Mar 03 00:00:00 CST 1999
, published
Tue Jul 18 00:00:00 CDT 2000
A method is presented for detecting eubacteria and fungus in biological samples, and, if present, determining their antibiotic sensitivity, where the presence and amount of eubacteria or fungus is measured by means of catalytically inactive murein binding...
US6531585 (B1), filed
Fri Feb 01 00:00:00 CST 1991
, published
Tue Mar 11 00:00:00 CST 2003
- PASTEUR INSTITUT
A previously isolated hepatitis B virus (HBV) integration in a 147 bp cellular DNA fragment linked to hepatocellular carcinoma (HCC) was used as a probe to clone the corresponding complementary DNA from a human liver cDNA library. Nucleotide sequence analysis...
US5098833 (A), filed
Thu Feb 23 00:00:00 CST 1989
, published
Tue Mar 24 00:00:00 CST 1992
- GENENTECH INC
DNA isolates coding for a lymphocyte homing receptor and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the lymphocyte homing receptor useful in therapeutic or diagnostic compositions.
US4299916 (A), filed
Wed Dec 26 00:00:00 CST 1979
, published
Tue Nov 10 00:00:00 CST 1981
- SYVA CO
An assay method and compositions are provided for determining the presence of an analyte in a sample. The analyte is a member of an immunological pair (mip) of immunogens-ligand and receptor. The method has two basic elements: a solid surface to which one of...
US7189534 (B2), filed
Tue May 21 00:00:00 CDT 2002
, published
Tue Mar 13 00:00:00 CDT 2007
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US6339071 (B1), filed
Thu Jan 20 00:00:00 CST 2000
, published
Tue Jan 15 00:00:00 CST 2002
- ANGIOGENE INC
The present invention relates to antisense oligonucleotides directed to the human cyclin E gene for inhibiting its expression, and to a method for inhibiting cellular proliferation. The antisense oligonucleotides of the present invention have been designed...
US4271145 (A), filed
Mon Oct 22 00:00:00 CDT 1979
, published
Tue Jun 02 00:00:00 CDT 1981
- MASSACHUSETTS GEN HOSPITAL
Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be...
US6270989 (B1), filed
Fri Mar 17 00:00:00 CST 1995
, published
Tue Aug 07 00:00:00 CDT 2001
- TRANSKARYOTIC THERAPIES INC
The invention relates to novel human DNA sequences, targeting constructs, and methods for producing novel genes encoding thrombopoietin, DNase I, and beta-interferon by homologous recombination. The targeting constructs comprise at least: a) a targeting...
US6261835 (B1), filed
Fri Jan 20 00:00:00 CST 1995
, published
Tue Jul 17 00:00:00 CDT 2001
- STRYKER CORP
Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural...
US5952462 (A), filed
Wed Nov 02 00:00:00 CST 1994
, published
Tue Sep 14 00:00:00 CDT 1999
- IGEN INT INC
Antigens capable of eliciting antibodies which can catalyze chemical reactions, in particular, the cleavage or formation of a peptide linkage, comprising a hapten or a hapten and a suitable carrier molecule are disclosed. Haptens include, among others, silicon...
US6117679 (A), filed
Mon Mar 25 00:00:00 CST 1996
, published
Tue Sep 12 00:00:00 CDT 2000
- MAXYGEN INC
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides...
US6927051 (B1), filed
Thu Apr 04 00:00:00 CST 2002
, published
Tue Aug 09 00:00:00 CDT 2005
- UNIV AKRON
An enzymatic chemical process comprising the steps of providing a biphasic liquid medium that includes one polar phase and one nonpolar phase in contact with each other, wherein at least one of the phases includes reactants, and adding a polymer-protein...
US4795699 (A), filed
Wed Jan 14 00:00:00 CST 1987
, published
Tue Jan 03 00:00:00 CST 1989
- HARVARD COLLEGE
This invention relates to T7-type DNA polymerases and method for using them.
US6803499 (B1), filed
Wed May 07 00:00:00 CDT 1997
, published
Tue Oct 12 00:00:00 CDT 2004
- DEKALB GENETICS CORP
This invention relates to a reproducible system for the production of stable, genetically transformed maize cells, and to methods of selecting cells that have been transformed. One method of selection disclosed employs the Streptomyces bar gene introduced by...
US6004929 (A), filed
Wed Mar 29 00:00:00 CST 1995
, published
Tue Dec 21 00:00:00 CST 1999
- ZYMOGENETICS INC
Dimeric proteins having substantially the same biological activity as PDGF are disclosed. More specifically, the protein may have two substantially identical polypeptide chains, each of the chains being substantially homologous to the A-chain of PDGF....
US7063829 (B2), filed
Wed Nov 06 00:00:00 CST 2002
, published
Tue Jun 20 00:00:00 CDT 2006
- INSTITU CURIE
The invention concerns peptide fragments of the WASP family proteins, or peptides derived from said fragments, and their uses in particular for preparing reagents for use in implementing a method for detecting or screening molecules with inhibiting or...
US6916648 (B2), filed
Wed Oct 24 00:00:00 CDT 2001
, published
Tue Jul 12 00:00:00 CDT 2005
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US7227005 (B1), filed
Thu Feb 25 00:00:00 CST 1999
, published
Tue Jun 05 00:00:00 CDT 2007
- HUMAN GENOME SCIENCES INC
Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by...
US7291329 (B2), filed
Mon Apr 15 00:00:00 CDT 2002
, published
Tue Nov 06 00:00:00 CST 2007
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US6204020 (B1), filed
Thu Mar 09 00:00:00 CST 1995
, published
Tue Mar 20 00:00:00 CST 2001
- CHIRON CORP
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant...
US5723323 (A), filed
Fri Dec 02 00:00:00 CST 1994
, published
Tue Mar 03 00:00:00 CST 1998
The present invention is directed to a process for the production of a peptide, polypeptide, or protein having a predetermined property. In accordance with one embodiment, the process begins by producing by way of synthetic polynucleotide coupling, stochastica...
US4888281 (A), filed
Tue Nov 27 00:00:00 CST 1984
, published
Tue Dec 19 00:00:00 CST 1989
- IGEN INC
A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal antibody under conditions permitting the formation of a complex...
US7172864 (B1), filed
Mon Jan 24 00:00:00 CST 2000
, published
Tue Feb 06 00:00:00 CST 2007
- NANOGEN
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations,...
US4766073 (A), filed
Wed Aug 13 00:00:00 CDT 1986
, published
Tue Aug 23 00:00:00 CDT 1988
- ZYMOGENETICS INC
Methods for expressing a variety of biologically active PDGF analogs in eucaryotic cells are disclosed. The methods generally comprise introducing into a eucaryotic host cell a DNA construct capable of directing the expression and secretion of biologically...
US6780982 (B2), filed
Tue Feb 06 00:00:00 CST 2001
, published
Tue Aug 24 00:00:00 CDT 2004
- THIRD WAVE TECH INC
The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags...
US6806359 (B1), filed
Mon Jun 05 00:00:00 CDT 1995
, published
Tue Oct 19 00:00:00 CDT 2004
- SALK INST FOR BIOLOGICAL STUDI
The present invention provides substantially pure DNA's comprised of sequences which encode proteins having the hormone-binding and/or transcription-activating characteristics of a glucocorticoid receptor, a mineralocorticoid receptor, or a thyroid hormone...
US6929947 (B2), filed
Fri Aug 31 00:00:00 CDT 2001
, published
Tue Aug 16 00:00:00 CDT 2005
- GENENTECH INC
The present invention is directed to nucleic acids encoding a secreted polypeptide that inhibits neoplastic growth in tumor cells. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules...
US6100042 (A), filed
Thu Oct 13 00:00:00 CDT 1994
, published
Tue Aug 08 00:00:00 CDT 2000
- CADUS PHARMACEUTICAL CORP
Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of alpha -factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a...
US6497872 (B1), filed
Wed Jun 07 00:00:00 CDT 1995
, published
Tue Dec 24 00:00:00 CST 2002
- NEUROSPHERES HOLDINGS LTD
The invention provides methods of transplanting multipotent neural stem cell progeny to a host by obtaining a population of cells derived from mammalian neural tissue containing at least one multipotent CNS multipotent neural stem cell; culturing the neural...
US4981784 (A), filed
Wed Nov 30 00:00:00 CST 1988
, published
Tue Jan 01 00:00:00 CST 1991
- SALK INST FOR BIOLOGICAL STUDI
US5910580 (A), filed
Mon Dec 08 00:00:00 CST 1997
, published
Tue Jun 08 00:00:00 CDT 1999
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding HI1648 of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US6271000 (B1), filed
Mon Dec 08 00:00:00 CST 1997
, published
Tue Aug 07 00:00:00 CDT 2001
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding enzyme mraY of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded enzyme, and a method for identifying compounds that inhibit said enzyme.
US4375414 (A), filed
Fri Jan 21 00:00:00 CST 1977
, published
Tue Mar 01 00:00:00 CST 1983
- STRAHILEVITZ MEIR
Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these drugs. These methods are based upon treating the psychoactive...
US6732573 (B2), filed
Mon Apr 22 00:00:00 CDT 2002
, published
Tue May 11 00:00:00 CDT 2004
- RHEOLOGICS INC
An apparatus and method for determining the viscosity of the circulating blood of a living being over plural shear rates caused by a decreasing pressure differential by monitoring the changing weight of the blood, or the changing level of a column of blood...
US5814469 (A), filed
Wed Jun 07 00:00:00 CDT 1995
, published
Tue Sep 29 00:00:00 CDT 1998
- CHIRON CORP
Methods are disclosed for diagnosing diseases resulting from undesirable cell adhesion of IL-1 receptor positive cells to biological materials, particular to endothelial cells, or autoimmune related diseases, preferably graft versus host disease, or IL-1...
US5824549 (A), filed
Fri Jun 02 00:00:00 CDT 1995
, published
Tue Oct 20 00:00:00 CDT 1998
- CHIRON CORP
Medicaments and methods of using the same are disclosed for treating or preventing diseases resulting from undesirable cell adhesion of IL-1 receptor positive cells to biological materials, particular to endothelial cells, or autoimmune related diseases,...
US6692917 (B2), filed
Mon Aug 27 00:00:00 CDT 2001
, published
Tue Feb 17 00:00:00 CST 2004
- THIRD WAVE TECH INC
The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on...
US5200333 (A), filed
Tue Mar 19 00:00:00 CST 1991
, published
Tue Apr 06 00:00:00 CDT 1993
- NEW ENGLAND BIOLABS INC
Methods for cloning restriction enzymes and their corresponding modification enzymes by selecting clones resistant to digestion by the restriction enzyme and subsequent selection of clones containing the restriction gene.
US6730778 (B2), filed
Wed Jun 09 00:00:00 CDT 1999
, published
Tue May 04 00:00:00 CDT 2004
- UPJOHN CO
The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The...
US5958730 (A), filed
Mon Dec 08 00:00:00 CST 1997
, published
Tue Sep 28 00:00:00 CDT 1999
- LILLY CO ELI
The invention provides isolated nucleic acid compounds encoding FtsY of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...
US4642411 (A), filed
Thu Feb 21 00:00:00 CST 1985
, published
Tue Feb 10 00:00:00 CST 1987
- MOLECULAR GENETICS RES DEV
This invention is direction to the production of novel plant genotypes or lines which produce increased free tryptophan levels and are resistant to inhibition by analogs which normally inhibit the activity of the enzyme anthranilate synthase before alteration....
US6051226 (A), filed
Thu Dec 30 00:00:00 CST 1993
, published
Tue Apr 18 00:00:00 CDT 2000
- INST OF VIROLOGY SLOVAK ACADEM
A new gene-MN-and proteins/polypeptides encoded therefrom are disclosed. Recombinant nucleic acid molecules for expressing MN proteins/polypeptides and fusion proteins are provided. Expression of the MN gene is disclosed as being associated with tumorigenicity...
US6429186 (B1), filed
Mon Sep 19 00:00:00 CDT 1994
, published
Tue Aug 06 00:00:00 CDT 2002
- GENENTECH INC
We have discovered that growth hormones form ternary complexes with their receptors in which site 1 on the hormone first binds to one molecule of receptor and then hormone site 2 then binds to another molecule of receptor, thereby producing a 1:2 complex. We...
US6312679 (B1), filed
Wed Mar 24 00:00:00 CST 1993
, published
Tue Nov 06 00:00:00 CST 2001
- DOW CHEMICAL CO
Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the...
US4801542 (A), filed
Mon Feb 25 00:00:00 CST 1985
, published
Tue Jan 31 00:00:00 CST 1989
- ZYMOGENETICS INC
US5583016 (A), filed
Thu Oct 27 00:00:00 CDT 1994
, published
Tue Dec 10 00:00:00 CST 1996
- GERON CORP
Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
US7074592 (B2), filed
Wed Jul 18 00:00:00 CDT 2001
, published
Tue Jul 11 00:00:00 CDT 2006
- GENETECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US5801154 (A), filed
Tue Apr 08 00:00:00 CDT 1997
, published
Tue Sep 01 00:00:00 CDT 1998
- ISIS PHARMACEUTICALS INC
Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP). In accordance with referred embodiments,...
US4581847 (A), filed
Tue Sep 04 00:00:00 CDT 1984
, published
Tue Apr 15 00:00:00 CST 1986
- MOLECULAR GENETICS RES DEV
This invention is directed to the production of novel plant genotypes or lines which produce increased free tryptophan levels and are resistant to inhibition by analogs which normally inhibit the activity of the enzyme anthranilate synthase before alteration....
US6184027 (B1), filed
Thu Mar 04 00:00:00 CST 1999
, published
Tue Feb 06 00:00:00 CST 2001
- SUPERVISORS LOUISIANA STATE UN
Catalytically inactive murein binding enzyme diagnostic reagents and methods and kits for detecting eubacteria and fungus in biological samples.
US5677195 (A), filed
Fri Nov 20 00:00:00 CST 1992
, published
Tue Oct 14 00:00:00 CDT 1997
- AFFYMAX TECH NV
A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the...
US5840496 (A), filed
Fri Jun 02 00:00:00 CDT 1995
, published
Tue Nov 24 00:00:00 CST 1998
- CHIRON CORP
Medicaments and methods of using the same are disclosed for treating or preventing diseases resulting from undesirable cell adhesion of IL-1 receptor positive cells to biological materials, particular to endothelial cells, or autoimmune related diseases,...
US4361549 (A), filed
Thu Apr 26 00:00:00 CST 1979
, published
Tue Nov 30 00:00:00 CST 1982
- ORTHO PHARMA CORP
Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells and cutaneous T lymphoma cells. The hybrid is formed by fusing splenocytes from immunized CAF1 mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic...
US7078221 (B2), filed
Wed Jan 03 00:00:00 CST 2001
, published
Tue Jul 18 00:00:00 CDT 2006
- STRYKER BIOTECH
Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural...
US7045289 (B2), filed
Thu May 24 00:00:00 CDT 2001
, published
Tue May 16 00:00:00 CDT 2006
- THIRD WAVE TECH INC
The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations...
US7456012 (B2), filed
Tue Dec 02 00:00:00 CST 2003
, published
Tue Nov 25 00:00:00 CST 2008
- CELLECTRICON AB
The invention provides hollow-tip-electrodes for spatially localized delivery of substances to one or more biological targets present in a population comprising target and non-target molecules, macromolecules, and/or cells. The invention also provides...
US5849870 (A), filed
Mon Jun 05 00:00:00 CDT 1995
, published
Tue Dec 15 00:00:00 CST 1998
- NOVARTIS FINANCE CORP
The present invention is drawn to pesticidal strains and proteins. Bacillus strains which are capable of producing pesticidal proteins and auxiliary proteins during vegetative growth are provided. Also provided are the purified proteins, nucleotide sequences...
US7385033 (B2), filed
Mon Jul 15 00:00:00 CDT 2002
, published
Tue Jun 10 00:00:00 CDT 2008
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US6117674 (A), filed
Thu Dec 29 00:00:00 CST 1994
, published
Tue Sep 12 00:00:00 CDT 2000
- NASA
A process for propagating a pathogen in a three-dimensional tissue mass cultured at microgravity conditions in a culture vessel containing culture media and a culture matrix is provided. The three-dimensional tissue mass is inoculated with a pathogen and...
US6852848 (B2), filed
Mon Jul 16 00:00:00 CDT 2001
, published
Tue Feb 08 00:00:00 CST 2005
- GENENTECH INC
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...
US4894228 (A), filed
Tue Jul 12 00:00:00 CDT 1988
, published
Tue Jan 16 00:00:00 CST 1990
- US HEALTH
The present invention provides an attenuated hepatitis A virus useful as a vaccine.
