Top 100 - Peptides

Human recombinant cysteine depleted interferon- beta muteins

US4588585 (A), filed Fri Sep 28 00:00:00 CDT 1984 , published Tue May 13 00:00:00 CDT 1986 - CETUS CORP

Muteins of biologically active proteins such as IFN- beta and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect...

Methods for treating systemic lupus erythematosus using anti-TNF antibodies and fragments thereof

US7128908 (B2), filed Tue Jul 12 00:00:00 CDT 2005 , published Tue Oct 31 00:00:00 CST 2006 - UNIV NEW YORK

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

PRO788 polypeptides

US7067628 (B2), filed Fri Oct 19 00:00:00 CDT 2001 , published Tue Jun 27 00:00:00 CDT 2006 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

PRO1571 polypeptides

US7332573 (B2), filed Thu Jun 27 00:00:00 CDT 2002 , published Tue Feb 19 00:00:00 CST 2008 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Non-a, non-b, non-c, non-c, non-d, non-e hepatitis reagents and methods for their use

US6720166 (B2), filed Mon Jun 05 00:00:00 CDT 1995 , published Tue Apr 13 00:00:00 CDT 2004 - ABBOTT LAB

Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to...

Highly purified gonadotropin compositions and process for preparing them

US7022822 (B1), filed Tue Jan 15 00:00:00 CST 2002 , published Tue Apr 04 00:00:00 CDT 2006 - INST MASSONE S A

Purification process of humanPurification process of human urinary gonadotropins of high biological activity and chemical purity absolutely free of foreign contaminating materials derived from the use of biological reagents or chromatography dyes, from crude...

Strepococcus pneumoniae gene sequence FtsH

US6136557 (A), filed Mon Dec 08 00:00:00 CST 1997 , published Tue Oct 24 00:00:00 CDT 2000 - LILLY CO ELI

The invention provides isolated nucleic acid compounds encoding FtsH of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...

PRO1757 antibodies

US7271250 (B2), filed Thu Jun 27 00:00:00 CDT 2002 , published Tue Sep 18 00:00:00 CDT 2007 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Kits for amplifying and detecting nucleic acid sequences

US6197563 (B1), filed Fri Nov 18 00:00:00 CST 1994 , published Tue Mar 06 00:00:00 CST 2001 - ROCHE MOLECULAR SYSTEMS INC

The present invention is directed to a process for amplifying any target nucleic acid sequence contained in a nucleic acid or mixture thereof using a thermostable enzyme. The process comprises treating separate complementary strands of the nucleic acid with a...

Vectors and compounds for expression of human protein C

US4775624 (A), filed Fri Feb 08 00:00:00 CST 1985 , published Tue Oct 04 00:00:00 CDT 1988 - LILLY CO ELI

The present invention comprises novel DNA compounds which encode human protein C activity. A variety of eukaryotic and prokaryotic recombinant DNA expression vectors have been constructed that comprise the novel protein C activity-encoding DNA and drive...

Methods of inhibiting TNFalpha in patients with neoplastic disease

US7214376 (B2), filed Fri Dec 07 00:00:00 CST 2001 , published Tue May 08 00:00:00 CDT 2007 - CENTOCOR INC

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

Methods of treating psoriasis with anti-TNF antibodies

US7335358 (B2), filed Mon Dec 04 00:00:00 CST 2006 , published Tue Feb 26 00:00:00 CST 2008 - UNIV NEW YORK

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

Methods of treating rheumatoid arthritis with anti-TNF antibodies

US7138118 (B2), filed Thu Dec 08 00:00:00 CST 2005 , published Tue Nov 21 00:00:00 CST 2006 - UNIV NEW YORK

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

Transgenic plants expressing assembled secretory antibodies

US6417429 (B1), filed Wed Nov 25 00:00:00 CST 1998 , published Tue Jul 09 00:00:00 CDT 2002 - SCRIPPS RESEARCH INST

The present invention relates to expression and assembly of foreign multimeric proteins-e.g., antibodies-in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional...

PRO1779 polypeptide

US7282566 (B2), filed Wed Apr 24 00:00:00 CDT 2002 , published Tue Oct 16 00:00:00 CDT 2007 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

PRO4400 polypeptides

US7361732 (B2), filed Wed May 08 00:00:00 CDT 2002 , published Tue Apr 22 00:00:00 CDT 2008 - GENENTECH INC

The present invention is directed to novel polypeptide and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptide...

Aminoacid derivatives as antihypertensives

US4374829 (A), filed Tue Feb 17 00:00:00 CST 1981 , published Tue Feb 22 00:00:00 CST 1983 - MERCK CO INC

The invention relates to new carboxyalkyl dipeptide derivatives and related compounds which are useful as antihypertensives.

Streptococcus pneumoniae gene sequence FtsZ

US6350866 (B1), filed Mon Dec 08 00:00:00 CST 1997 , published Tue Feb 26 00:00:00 CST 2002 - LILLY CO ELI

The invention provides isolated nucleic acid compounds encoding FtsZ of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...

Streptococcus pneumoniae gene sequence GCP

US6268175 (B1), filed Mon Dec 08 00:00:00 CST 1997 , published Tue Jul 31 00:00:00 CDT 2001 - LILLY CO ELI

The invention provides isolated nucleic acid compounds encoding gcp of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...

Streptococcus pneumoniaegene sequence era

US6071724 (A), filed Mon Dec 08 00:00:00 CST 1997 , published Tue Jun 06 00:00:00 CDT 2000 - LILLY CO ELI

The invention provides isolated nucleic acid compounds encoding Era of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...

Prodrugs activated by targeted catalytic proteins

US6702705 (B1), filed Wed Feb 22 00:00:00 CST 1995 , published Tue Mar 09 00:00:00 CST 2004 - IGEN INT INC

Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.

Pro1017 polypeptides

US7019115 (B2), filed Thu Oct 18 00:00:00 CDT 2001 , published Tue Mar 28 00:00:00 CST 2006 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Apparatus and method for multiple simultaneous synthesis

US5766556 (A), filed Tue Dec 31 00:00:00 CST 1996 , published Tue Jun 16 00:00:00 CDT 1998 - WARNER LAMBERT CO

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters...

PRO4406 polypeptide

US7343721 (B2), filed Mon Apr 15 00:00:00 CDT 2002 , published Tue Mar 18 00:00:00 CDT 2008 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Derivatized oligonucleotides having improved uptake and other properties

US6919439 (B2), filed Thu May 23 00:00:00 CDT 2002 , published Tue Jul 19 00:00:00 CDT 2005 - ISIS PHARMACEUTICALS INC

Linked nucleosides having at least one functionalized nucleosid that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitamin, lipid soluble...

Vaccine for clostridium botulinum neurotoxin

US5919665 (A), filed Thu Mar 16 00:00:00 CST 1995 , published Tue Jul 06 00:00:00 CDT 1999 - OPHIDIAN PHARM INC

The present invention includes recombinant proteins derived from Clostridium botulinum toxins. In particular, soluble recombinant Clostridium botulinum type A toxin proteins are provided. Methods which allow for the isolation of recombinant proteins free of...

PRO1374 polypeptides

US7297767 (B2), filed Wed Jun 26 00:00:00 CDT 2002 , published Tue Nov 20 00:00:00 CST 2007 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

PRO1339 polypeptides

US7319137 (B2), filed Wed Jun 26 00:00:00 CDT 2002 , published Tue Jan 15 00:00:00 CST 2008 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule

US6060056 (A), filed Wed Sep 08 00:00:00 CDT 1993 , published Tue May 09 00:00:00 CDT 2000 - JOLLA PHARMA

Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are...

Directed evolution of novel binding proteins

US5837500 (A), filed Mon Apr 03 00:00:00 CDT 1995 , published Tue Nov 17 00:00:00 CST 1998 - DYAX CORP

In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a...

Growth hormone variants

US6780613 (B1), filed Wed Jun 07 00:00:00 CDT 1995 , published Tue Aug 24 00:00:00 CDT 2004 - GENENTECH INC

The invention provides methods for the systematic analysis of the structure and function of polypeptides by identifying active domains which influence the activity of the polypeptide with a target substance. Such active domains are determined by substituting...

Nucleic acids to PRO1387 polypeptides

US7029873 (B2), filed Tue Nov 20 00:00:00 CST 2001 , published Tue Apr 18 00:00:00 CDT 2006 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Uses of synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites

US6916604 (B2), filed Fri Mar 07 00:00:00 CST 2003 , published Tue Jul 12 00:00:00 CDT 2005 - WASHINGTON RES FOUND

Peptides synthesized to match the human alpha1 (I) and alpha2 (I) amino-telopeptide sequences of type I collagen degradation products in body fluids, preferably either Asp-GIu-Lys-Ser-Thr-Gly-Gly (SEQ ID NO:5) or Gln-Tyr-Asp-Gly-Lys-Gly-Val-Gly (SEQ ID NO:6)....

Methods of treatment of fistulas in Crohn's disease with anti-TNF antibodies

US7223396 (B2), filed Thu Dec 12 00:00:00 CST 2002 , published Tue May 29 00:00:00 CDT 2007 - UNIV NEW YORK

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

CTLA4/CD28Ig hybrid fusion proteins and uses thereof

US6090914 (A), filed Fri Apr 15 00:00:00 CDT 1994 , published Tue Jul 18 00:00:00 CDT 2000 - SQUIBB BRISTOL MYERS CO

The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid...

Methods for treating sarcoidosis using anti-TNF antibodies and fragments thereof

US7135179 (B2), filed Wed Jul 13 00:00:00 CDT 2005 , published Tue Nov 14 00:00:00 CST 2006 - UNIV NEW YORK

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

Methods of treating inflammation associated with viral infection with anti-TNF antibodies

US7169386 (B1), filed Thu Jan 10 00:00:00 CST 2002 , published Tue Jan 30 00:00:00 CST 2007 - CENTOCOR INC

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

Apparatus for multiple simultaneous synthesis

US5567391 (A), filed Mon Jun 05 00:00:00 CDT 1995 , published Tue Oct 22 00:00:00 CDT 1996 - WARNER LAMBERT CO

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters...

PRO1758 polypeptides

US7291704 (B2), filed Thu Jun 27 00:00:00 CDT 2002 , published Tue Nov 06 00:00:00 CST 2007 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

PRO1571 antibodies

US7304143 (B2), filed Thu Jun 27 00:00:00 CDT 2002 , published Tue Dec 04 00:00:00 CST 2007 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Recombinant anti-TNF-alpha antibodies

US7179893 (B2), filed Fri Apr 07 00:00:00 CDT 2006 , published Tue Feb 20 00:00:00 CST 2007 - CENTOCOR INC

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

Process for amplifying nucleic acid sequences

US4683202 (A), filed Fri Oct 25 00:00:00 CDT 1985 , published Tue Jul 28 00:00:00 CDT 1987 - CETUS CORP

No title available

US4683202 (B1), filed Fri Oct 25 00:00:00 CDT 1985 , published Tue Nov 27 00:00:00 CST 1990 - CETUS CORP

Methods of inhibiting or neutralizing TNFalpha in patients with tissue injury

US7404955 (B2), filed Tue Aug 02 00:00:00 CDT 2005 , published Tue Jul 29 00:00:00 CDT 2008 - UNIV NEW YORK

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

Methods of treating TNF alpha -mediated disease using chimeric anti-TNF antibodies

US5919452 (A), filed Fri Feb 04 00:00:00 CST 1994 , published Tue Jul 06 00:00:00 CDT 1999 - UNIV NEW YORK

Treatment of tumor necrosis factor, TNF, mediated pathologies is provided by administering anti-TNF compounds, such as anti-TNF antibodies and anti-TNF peptides, which compounds are specific for tumor necrosis factor- alpha (TNF alpha ) or tumor necrosis...

Secreted and transmembrane polypeptides and nucleic acids encoding the same

US7223838 (B2), filed Fri May 03 00:00:00 CDT 2002 , published Tue May 29 00:00:00 CDT 2007 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Methods for restoring wild-type p53 gene function

US6800617 (B1), filed Mon Mar 22 00:00:00 CST 1993 , published Tue Oct 05 00:00:00 CDT 2004 - UNIV JOHNS HOPKINS

Methods are provided for restoring wild-type p53 gene function to a cell. Such methods include gene therapy. Typically, this will stop tumor cells from proliferating.

Semi-synthesis of human insulin

US4320196 (A), filed Wed Apr 09 00:00:00 CST 1980 , published Tue Mar 16 00:00:00 CST 1982 - SHIONOGI CO

A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.

Methods for the propagation, isolation, identification, and preparation of human immunodeficiency virus type 1 (HIV-1)

US6627395 (B1), filed Tue Jun 06 00:00:00 CDT 1995 , published Tue Sep 30 00:00:00 CDT 2003 - US HEALTH

The identification, separation, purification, and propagation of the HIV-1 virus is provided. Moreover, the preparation of antigens from HIV-1 is further provided. The identification of HIV-1 involves the purification of a virus sample from lymphocytes and...

Recycle process for the production of low-cost soluble collagen

US5460967 (A), filed Fri May 27 00:00:00 CDT 1994 , published Tue Oct 24 00:00:00 CDT 1995 - RANPAK CORP

The invention includes a method that produces a low cost aqueous solution of solubilized collagen by the steps of: (a) providing an aqueous ground slurry of insoluble collagen and adjusting the pH of said slurry to obtain activity for a proteolytic enzyme...

Recycle process for the production of low-cost soluble collagen

US5460967 (B1), filed Fri May 27 00:00:00 CDT 1994 , published Tue Mar 10 00:00:00 CST 1998 - RANPAK CORP CONCORD

HIV immunoassays using gag polypeptides

US6458527 (B1), filed Mon Jun 28 00:00:00 CDT 1993 , published Tue Oct 01 00:00:00 CDT 2002 - CHIRON CORP

Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to...

Active programmable electronic devices for molecular biological analysis and diagnostics

US5605662 (A), filed Mon Nov 01 00:00:00 CST 1993 , published Tue Feb 25 00:00:00 CST 1997 - NANOGEN INC

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization,...

Lactalbumin production process

US7053185 (B1), filed Tue Aug 15 00:00:00 CDT 2000 , published Tue May 30 00:00:00 CDT 2006 - HAMLET PHARMA AB

A method for producing an oligomeric form of alpha-lactalbumin which is in the molten globule-like state is described. The method suitably comprises exposing a source of alpha-lactalbumin in which the alpha-lactalbumin is preferably in the molten globule-like...

Fluorescent proteins

US6919186 (B2), filed Fri Sep 28 00:00:00 CDT 2001 , published Tue Jul 19 00:00:00 CDT 2005 - AMERSHAM PLC

The present invention provides novel engineered derivatives of green fluorescent protein (GFP) which have an amino acid sequence which is modified by amino acid substitution compared with the amino acid sequence of wild type Green Fluorescent Protein. The...

Method of stimulating epithelial cells using keratinocyte growth factor (KGF) and method of inhibiting KGF activity

US6833132 (B1), filed Wed May 31 00:00:00 CDT 1995 , published Tue Dec 21 00:00:00 CST 2004 - US HEALTH

Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various...

Osteogenic proteins

US7176284 (B2), filed Fri May 02 00:00:00 CDT 2003 , published Tue Feb 13 00:00:00 CST 2007 - STRYKER CORP

Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors...

PRO1339 antibodies

US7317093 (B2), filed Wed Jun 26 00:00:00 CDT 2002 , published Tue Jan 08 00:00:00 CST 2008 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

DNA encoding novel polypeptide having Factor Xa inhibitory activity

US5783421 (A), filed Tue Jun 06 00:00:00 CDT 1995 , published Tue Jul 21 00:00:00 CDT 1998 - BIO TECHNOLOGY GENERAL CORP

A novel polypeptide derived from the leech Hirudo medicinalis was found to be able to inhibit Factor Xa thereby reducing the extent of blood coagulation. The polypeptide is useful in treating conditions of excessive blood coagulation. A recombinant organism...

Nucleic acids encoding proteins that stimulate the proliferation of t-lymphocytes

US6838554 (B2), filed Fri Sep 14 00:00:00 CDT 2001 , published Tue Jan 04 00:00:00 CST 2005 - GENETECH INC

The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags...

Modifications of the VEGF Receptor-2 Protein and methods of use

US6784285 (B1), filed Fri Feb 18 00:00:00 CST 2000 , published Tue Aug 31 00:00:00 CDT 2004 - AGOURON PHARMA

A 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key enzyme in angiogenesis, has been determined in an unliganded, phosphorylated state. This protein...

Nucleic acids encoding soluble human FLK-2 extracellular domain

US5621090 (A), filed Fri Jun 26 00:00:00 CDT 1992 , published Tue Apr 15 00:00:00 CDT 1997 - UNIV PRINCETON

Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid...

Methods of inhibiting TNFalpha activity in the blood of a patient

US7425330 (B2), filed Mon Oct 16 00:00:00 CDT 2006 , published Tue Sep 16 00:00:00 CDT 2008 - UNIV NEW YORK

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

Conotoxins I

US5700778 (A), filed Fri Jun 02 00:00:00 CDT 1995 , published Tue Dec 23 00:00:00 CST 1997 - SALK INST FOR BIOLOGICAL STUDI

Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion...

Tetrapeptide

US4792525 (A), filed Mon Jun 17 00:00:00 CDT 1985 , published Tue Dec 20 00:00:00 CST 1988 - JOLLA CANCER RES FOUND

The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same cell-attachent activity as fibronectin and the peptide...

Methods of treating joint inflammation with anti-TNF antibodies

US7166284 (B2), filed Fri Feb 21 00:00:00 CST 2003 , published Tue Jan 23 00:00:00 CST 2007 - CENTOCOR INC

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

Compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein

US7101969 (B1), filed Thu Oct 12 00:00:00 CDT 2000 , published Tue Sep 05 00:00:00 CDT 2006 - TARGANTA THERAPEUTICS

This invention relates to newly identified polynucleotides and polypeptides, and their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of a...

Polypeptide

US4517686 (A), filed Wed Aug 04 00:00:00 CDT 1982 , published Tue May 21 00:00:00 CDT 1985 - JOLLA CANCER RES FOUND

A polypeptide having the cell-attaching activity of fibronectin. The polypeptide has 108 amino acid residues and the formula: H-Ile-Gly-Gln-Gln-Ser-Thr-Val-Ser-Asp-Val-Pro-Arg-Asp-Leu-Glu-Val-Val- Ala-Ala-Thr-Pro-Thr-Ser-Leu-Leu-Ile-Ser-Trp-Asp-Ala-Pro-Ala-Val...

In Vivo production and delivery of erythropoietin or insulinotropin for gene therapy

US6846676 (B2), filed Tue Jun 08 00:00:00 CDT 1999 , published Tue Jan 25 00:00:00 CST 2005 - TRANSKARYOTIC THERAPIES INC

The invention provides primary and secondary cells that are transfected with a nucleic acid molecule that encodes erythropoietin, clonal or heterogenous strains of such cells, and methods of producing these cell strains.

NANBV diagnostics and vaccines

US6861212 (B1), filed Mon May 15 00:00:00 CDT 1995 , published Tue Mar 01 00:00:00 CST 2005 - CHIRON CORP

A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBH), but which are absent from individuals infected...

Methods and compositions using fibrin monomer to make a fibrin sealant

US5750657 (A), filed Mon Oct 18 00:00:00 CDT 1993 , published Tue May 12 00:00:00 CDT 1998 - SQUIBB BRISTOL MYERS CO

The subject invention relates to methods and compositions using nondynamic fibrin monomer which is selectively converted to a fibrin polymer which serves as the fibrin sealant.

DNA-construct for the tissue-specific expression of a blood coagulation factor

US6884616 (B1), filed Thu Apr 27 00:00:00 CDT 2000 , published Tue Apr 26 00:00:00 CDT 2005 - ZLB BEHRING GMBH

A DNA-construct has been disclosed which is suitable for a tissue-specific expression of a blood coagulation factor like Factor IX, which comprises a DNA coding for an amino acid sequence of a blood coagulation factor and a DNA coding for a promoter which is...

Streptococcus pneumoniae gene sequence Dpj

US6060282 (A), filed Mon Dec 08 00:00:00 CST 1997 , published Tue May 09 00:00:00 CDT 2000 - LILLY CO ELI

The invention provides isolated nucleic acid compounds encoding dpj of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said...

MHC conjugates useful in ameliorating autoimmunity

US6451314 (B1), filed Fri Jun 23 00:00:00 CDT 2000 , published Tue Sep 17 00:00:00 CDT 2002 - ANERGEN INC

The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These complexes are useful in treating autoimmune disease.

Anti-TNF antibodies and peptides of human tumor necrosis factor

US6835823 (B2), filed Mon Jan 08 00:00:00 CST 2001 , published Tue Dec 28 00:00:00 CST 2004 - UNIV NEW YORK

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding...

Nucleic acid encoding anti-IgE antibodies

US7351816 (B2), filed Tue Oct 19 00:00:00 CDT 2004 , published Tue Apr 01 00:00:00 CDT 2008 - GENENTECH INC

The present invention describes IgE antagonists (including variant anti-IgE antibodies) and their use in diagnosis, therapy or prophylaxis of allergic and other IgE-mediated disorders, including asthma, food allergies, hypersensitivity and anaphylactic...

Transgenic non-human animals for producing heterologous antibodies

US5789650 (A), filed Wed Mar 18 00:00:00 CST 1992 , published Tue Aug 04 00:00:00 CDT 1998 - GENPHARM INT

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are...

Extraction methods for preparing thromboplastin reagents

US5426031 (A), filed Tue May 25 00:00:00 CDT 1993 , published Tue Jun 20 00:00:00 CDT 1995 - BAXTER DIAGNOSTICS INC

The Prothrombin Time (PT) is used as a screening test for blood coagulation factor deficiencies and for monitoring oral anti-coagulant therapy using coumadin. Thromboplastin reagents activate the extrinsic pathway of coagulation and are the basis for the...

Recombinant DNA which codes for interleukin-1

US5985657 (A), filed Wed Jun 07 00:00:00 CDT 1995 , published Tue Nov 16 00:00:00 CST 1999 - NEW ENGLAND MEDICAL CENTER INC

The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA...

Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors

US6951955 (B2), filed Thu Sep 18 00:00:00 CDT 2003 , published Tue Oct 04 00:00:00 CDT 2005 - WYETH CORP

The invention is a process for the preparation of compounds of the Formula I: where RSUB1/SUB, RSUB2/SUB, RSUB3/SUB, RSUB4 /SUBand RSUB5 /SUBare defined in the specification, which are intermediates useful for the preparation of tubulin inhibitors which are...

Antibodies that bind PRO4994 polypeptides

US7153941 (B2), filed Fri May 10 00:00:00 CDT 2002 , published Tue Dec 26 00:00:00 CST 2006 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Modified vaccinia virus

US4603112 (A), filed Wed Dec 08 00:00:00 CST 1982 , published Tue Jul 29 00:00:00 CDT 1986 - HEALTH RESEARCH INC

What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified...

Novel receptors for efficient determination of ligands and their antagonists or agonists

US4859609 (A), filed Wed Apr 30 00:00:00 CDT 1986 , published Tue Aug 22 00:00:00 CDT 1989 - GENENTECH INC

PRO1374 antibodies

US7297776 (B2), filed Wed Jun 26 00:00:00 CDT 2002 , published Tue Nov 20 00:00:00 CST 2007 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Simian immunodeficiency virus peptides with antifusogenic and antiviral activities

US6017536 (A), filed Tue Dec 20 00:00:00 CST 1994 , published Tue Jan 25 00:00:00 CST 2000 - TRIMERIS INC

The present invention relates to peptides which exhibit antifusogenic and antiviral activities. The peptides of the invention consist of a 16 to 39 amino acid region of a simian immunodeficiency virus (SIV) protein. These regions were identified through...

Osteogenic devices

US6919308 (B2), filed Tue Dec 17 00:00:00 CST 2002 , published Tue Jul 19 00:00:00 CDT 2005 - STRYKER CORP

Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors...

Detecting eubacteria and fungus and determining their antibiotic sensitivity by using catalytically inactive murein binding enzymes

US6090573 (A), filed Wed Mar 03 00:00:00 CST 1999 , published Tue Jul 18 00:00:00 CDT 2000

A method is presented for detecting eubacteria and fungus in biological samples, and, if present, determining their antibiotic sensitivity, where the presence and amount of eubacteria or fungus is measured by means of catalytically inactive murein binding...

Steroid/thyroid hormone receptor-related gene which is inappropriately expressed in human hepatocellular carcinoma and which is a retinoic acid receptor

US6531585 (B1), filed Fri Feb 01 00:00:00 CST 1991 , published Tue Mar 11 00:00:00 CST 2003 - PASTEUR INSTITUT

A previously isolated hepatitis B virus (HBV) integration in a 147 bp cellular DNA fragment linked to hepatocellular carcinoma (HCC) was used as a probe to clone the corresponding complementary DNA from a human liver cDNA library. Nucleotide sequence analysis...

DNA sequence encoding a functional domain of a lymphocyte homing receptor

US5098833 (A), filed Thu Feb 23 00:00:00 CST 1989 , published Tue Mar 24 00:00:00 CST 1992 - GENENTECH INC

DNA isolates coding for a lymphocyte homing receptor and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the lymphocyte homing receptor useful in therapeutic or diagnostic compositions.

Hybrid immunoglobulins

US6406697 (B1), filed Tue Aug 05 00:00:00 CDT 1997 , published Tue Jun 18 00:00:00 CDT 2002 - GENENTECH INC

Novel polypeptides are provided, together with methods for making and using them, and nucleic acids encoding them. These polypeptides are useful as cell surface adhesion molecules and ligands, and are useful in therapeutic or diagnostic compositions and...

Methods of treating disseminated intravascular coagulation using anti-TNF antibodies

US7135178 (B2), filed Thu Jun 20 00:00:00 CDT 2002 , published Tue Nov 14 00:00:00 CST 2006 - UNIV NEW YORK

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful for therapy of TNFalpha-mediated pathologies and conditions, including vascular inflammatory pathologies.

Novel substituted phenylacetic acid amide compounds

US4250192 (A), filed Wed Apr 25 00:00:00 CST 1979 , published Tue Feb 10 00:00:00 CST 1981 - CIBA GEIGY CORP

Phenylacetic acid amide compounds of the formula IMAGE (I) in which R1 is hydrogen, lower alkyl, lower alkoxy, halogen having an atomic number of not more than 35 or trifluoromethyl, R2 is hydrogen, lower alkyl, lower alkoxy, halogen having an atomic...

PRO1482 antibodies

US7378486 (B2), filed Thu Jun 27 00:00:00 CDT 2002 , published Tue May 27 00:00:00 CDT 2008 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Method for making intermediates useful in synthesis of retroviral protease inhibitors

US6388094 (B1), filed Mon Nov 01 00:00:00 CST 1999 , published Tue May 14 00:00:00 CDT 2002 - SEARLE CO

A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

Process for producing antibodies to hepatitis virus and cell lines therefor

US4271145 (A), filed Mon Oct 22 00:00:00 CDT 1979 , published Tue Jun 02 00:00:00 CDT 1981 - MASSACHUSETTS GEN HOSPITAL

Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be...

Protein production and delivery

US6270989 (B1), filed Fri Mar 17 00:00:00 CST 1995 , published Tue Aug 07 00:00:00 CDT 2001 - TRANSKARYOTIC THERAPIES INC

The invention relates to novel human DNA sequences, targeting constructs, and methods for producing novel genes encoding thrombopoietin, DNase I, and beta-interferon by homologous recombination. The targeting constructs comprise at least: a) a targeting...

Nucleotide sequences encoding osteogenic proteins

US6261835 (B1), filed Fri Jan 20 00:00:00 CST 1995 , published Tue Jul 17 00:00:00 CDT 2001 - STRYKER CORP

Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural...

PRO4352 polypeptides

US7291706 (B2), filed Mon Jul 01 00:00:00 CDT 2002 , published Tue Nov 06 00:00:00 CST 2007 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

PRO6015 polypeptides

US7312310 (B2), filed Tue Jul 02 00:00:00 CDT 2002 , published Tue Dec 25 00:00:00 CST 2007 - GENENTECH INC

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid...

Methods of using human Zven proteins

US7179787 (B2), filed Tue Nov 16 00:00:00 CST 2004 , published Tue Feb 20 00:00:00 CST 2007 - ZYMOGENETICS INC

The present invention provides novel uses two members of a new family of human proteins, designated as "Zven," as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which...

Top 100 US Patents in Peptides

section c - chemistry; metallurgy > organic chemistry > peptides