Top 100 US Patents in Heterocyclic Compounds
section c - chemistry; metallurgy > organic chemistry > heterocyclic compounds
Sorted by IPQ® Score, an objective measure of patent quality. View scores and methodology at PatentRatings.com. You can also view all by publication date instead.
US4594437 (A), filed
Thu Feb 21 00:00:00 CST 1985
, published
Tue Jun 10 00:00:00 CDT 1986
- UC UNITAS CORP
Tocopherols are recovered from deodorizer sludge by urea complex formation with the contaminating fatty acids and glycerides of fatty acids in the presence of a solvent.
US5807977 (A), filed
Thu Jan 12 00:00:00 CST 1995
, published
Tue Sep 15 00:00:00 CDT 1998
- AEROJET GENERAL CO
This application is directed to novel fluorinated polymers and prepolymers derived from mono-substituted oxetane monomers having fluorinated alkoxymethylene side-chains and the method of making these compositions. The mono-substituted fluorinated oxetane...
US6350753 (B1), filed
Wed Sep 30 00:00:00 CDT 1998
, published
Tue Feb 26 00:00:00 CST 2002
- IAF BIOCHEM INT
Nucleoside analogues containing a 1,3-dioxolane structure are suitable antiviral agents, particulary for the treatment of the HIV infections in mammals, especially humans. Examples of the nucleoside analogues include:cis-2-acetoxymethyl-4-(thymin-1'-yl)-1,3,-d...
US6465500 (B1), filed
Mon Oct 23 00:00:00 CDT 2000
, published
Tue Oct 15 00:00:00 CDT 2002
- PFIZER
Compounds of the formulawhere W isn is 0, 1, or 2; m is 0, 1, 2, or 3: Y and G are each independently oxygen or sulfur; Z is -O-, -S-, -NH, or -CH2; R1 is hydrogen, C1 to C8 alkyl, substituted C1 to C8 alkyl substituted with one hydroxy, C3 to C8 alkenyl, C3...
US6702705 (B1), filed
Wed Feb 22 00:00:00 CST 1995
, published
Tue Mar 09 00:00:00 CST 2004
- IGEN INT INC
Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.
US6967201 (B1), filed
Mon May 06 00:00:00 CDT 2002
, published
Tue Nov 22 00:00:00 CST 2005
- LILLY CO ELI
The present invention provides serotonergic benzofurylpiperazines of Formula I: where: A is a piperazine of formula: and R, RSUP1/SUP, RSUP2/SUP, RSUP3/SUP, RSUP4/SUP, RSUP5/SUP, RSUP5'/SUP, RSUP6/SUP, RSUP6'/SUP, RSUP7/SUP, RSUP7'/SUP, RSUP8/SUP, and...
US6770673 (B1), filed
Mon Feb 01 00:00:00 CST 1999
, published
Tue Aug 03 00:00:00 CDT 2004
- PARACURE INC
Compositions and kits containing a first chemotherapeutic agent that includes arglabin or a derivative thereof and a second chemotherapeutic agent are described. The compositions and kits are effective for treating cancer in a human patient. Methods for...
US5700840 (A), filed
Tue May 23 00:00:00 CDT 1995
, published
Tue Dec 23 00:00:00 CST 1997
- MONSANTO CO
Fluorinated alkene compounds useful for controlling nematodes, insects, and acarids that prey on agricultural crops, these compounds having the formula BrCF2CFClCH2CO-R where R is R1 or R2. R1 is -SR5, halogen, -NHOH or -NR5R6, where R5 and R6 are independentl...
US6911476 (B2), filed
Thu Aug 15 00:00:00 CDT 2002
, published
Tue Jun 28 00:00:00 CDT 2005
- LILLY CO ELI
The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a patient and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
US4612132 (A), filed
Fri Apr 12 00:00:00 CST 1985
, published
Tue Sep 16 00:00:00 CDT 1986
- CHEVRON RES
Disclosed are additives which are useful as dispersants in lubricating oils, gasolines, marine crankcase oils and hydraulic oils. In particular, disclosed are polyamino alkenyl or alkyl succinimides which contain carbamate functionalities.
US4694014 (A), filed
Fri Sep 26 00:00:00 CDT 1986
, published
Tue Sep 15 00:00:00 CDT 1987
- CIBA GEIGY CORP
The invention relates to novel compounds of the formulae IMAGE (Ia) IMAGE (Ib) IMAGE (I*) in which formulae R'is C1-C5alkyl, C1-C5alkoxy, halogen or trifluoromethyl, R'' is C1-C5alkyl or halogen, m is 1 ot 3 and n is 0 to 1, X is oxygen or sulfur, Y is...
US5859035 (A), filed
Thu Mar 27 00:00:00 CST 1997
, published
Tue Jan 12 00:00:00 CST 1999
- MERCK CO INC
The present invention is directed to compounds which inhibit famesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention...
US5315013 (A), filed
Wed Aug 05 00:00:00 CDT 1992
, published
Tue May 24 00:00:00 CDT 1994
- DU PONT
Substituted pyrazoles such as IMAGE and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
US4921869 (A), filed
Fri Aug 19 00:00:00 CDT 1988
, published
Tue May 01 00:00:00 CDT 1990
- DU PONT
Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-1-oxo-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]ac etamide, possess useful antibacterial activity.
US5760068 (A), filed
Fri Sep 06 00:00:00 CDT 1996
, published
Tue Jun 02 00:00:00 CDT 1998
- SEARLE CO
PCT No. PCT/US94/12720 Sec. 371 Date Sep. 6, 1996 Sec. 102(e) Date Sep. 6, 1996 PCT Filed Nov. 14, 1994 PCT Pub. No. WO95/15316 PCT Pub. Date Jun. 8, 1995A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and...
US5587105 (A), filed
Mon Jun 05 00:00:00 CDT 1995
, published
Tue Dec 24 00:00:00 CST 1996
Low molecular weight resins that usually are aliphatic and that include crosslinking thermal functional groups are useful as liquid molding compounds for reaction injection molding or resin transfer molding. The compounds eliminate the need to handle solvents...
US6569855 (B2), filed
Mon Jun 25 00:00:00 CDT 2001
, published
Tue May 27 00:00:00 CDT 2003
- PROCTER GAMBLE
The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure...
US6872742 (B2), filed
Mon Jul 01 00:00:00 CDT 2002
, published
Tue Mar 29 00:00:00 CST 2005
- PROCTER GAMBLE
The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure...
US4240960 (A), filed
Mon Mar 19 00:00:00 CST 1979
, published
Tue Dec 23 00:00:00 CST 1980
- BRISTOL MYERS CO
Trimethylsilyl or another easily hydrolyzed ester of 6-trimethylsilyloxycarbonylaminopenicillanic acid was prepared by bubbling dry carbon dioxide into an anhydrous solution of the corresponding 6-trimethylsilylaminopenicillanate and found to be a useful...
US4273778 (A), filed
Wed Dec 26 00:00:00 CST 1979
, published
Tue Jun 16 00:00:00 CDT 1981
- BEECHAM GROUP LTD
This invention relates to novel substituted benzamides having useful pharmacological properties, to pharmaceutical compositions containing them, and to a process for their preparation. N-(2-Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide, 1-ethyl-2(2-me...
US5003080 (A), filed
Wed Feb 01 00:00:00 CST 1989
, published
Tue Mar 26 00:00:00 CST 1991
- WARNER LAMBERT CO
US6051574 (A), filed
Wed Feb 10 00:00:00 CST 1999
, published
Tue Apr 18 00:00:00 CDT 2000
- MERCK CO INC
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention...
US7476740 (B2), filed
Thu Mar 27 00:00:00 CST 2003
, published
Tue Jan 13 00:00:00 CST 2009
- ORGANIX INC
The present invention provides novel tropane compounds and methods for their use.
US4271313 (A), filed
Fri Oct 26 00:00:00 CDT 1979
, published
Tue Jun 02 00:00:00 CDT 1981
- UPJOHN CO
The present invention provides novel 19-hydroxy-cis-4,5-didehydro-13,14-dihydro-PG1 Analogs methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
US4277484 (A), filed
Fri Feb 08 00:00:00 CST 1980
, published
Tue Jul 07 00:00:00 CDT 1981
- CIBA GEIGY CORP
2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula IMAGE or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.
US6545016 (B1), filed
Fri Jun 07 00:00:00 CDT 2002
, published
Tue Apr 08 00:00:00 CDT 2003
- 3M INNOVATIVE PROPERTIES CO
Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety...
US4256855 (A), filed
Thu Nov 16 00:00:00 CST 1978
, published
Tue Mar 17 00:00:00 CST 1981
- DOW CHEMICAL CO
Compounds represented by the formula IMAGE and addition polymers thereof where m is an integer from 2 to about 10, x-is chlorine, hydroxy, carboxy or -AC-R)=CH2 -R is hydrogen or methyl, -R' is an ethylene or propylene group and -AC-R)=CH2 is one of IMAGE ...
US7144900 (B2), filed
Fri Sep 10 00:00:00 CDT 2004
, published
Tue Dec 05 00:00:00 CST 2006
- TAKEDA PHARMACEUTICAL
Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for...
US5968916 (A), filed
Mon Jan 12 00:00:00 CST 1998
, published
Tue Oct 19 00:00:00 CDT 1999
- MONSANTO CO
Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds are particularly useful for systemic control of pests.
US4283558 (A), filed
Fri Oct 26 00:00:00 CDT 1979
, published
Tue Aug 11 00:00:00 CDT 1981
- UPJOHN CO
The present invention provides novel 2-decarboxy-2-hydroxymethyl-19,20-didehydro-13,14-dihydro-PG1 compounds methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
US4297497 (A), filed
Fri Jul 13 00:00:00 CDT 1979
, published
Tue Oct 27 00:00:00 CST 1981
- GOODRICH CO B F
Several novel syntheses have been discovered for preparation of 2-keto-1,4-diazacycloalkanes and their derivatives. Trans isomers of polysubstituted quinoxalin-2-ones may now be prepared.
US6031093 (A), filed
Thu Apr 06 00:00:00 CDT 1995
, published
Tue Feb 29 00:00:00 CST 2000
- SMITHKLINE BEECHAM PLC
A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts...
US6031093 (C1), filed
Thu Apr 06 00:00:00 CDT 1995
, published
Tue Oct 16 00:00:00 CDT 2001
- SMITHKLINE BEECHAM PLC
US4376769 (A), filed
Fri Jun 19 00:00:00 CDT 1981
, published
Tue Mar 15 00:00:00 CST 1983
- SCHERING CORP
Disclosed herein are novel tetrahydro imidazo thiazoles, tetrahydro imidazo thiazines, hexahydro imidazo thiazepines and hexahydro imidazo thiazocines, intermediates for the preparation thereof, methods of using the compounds as anti-inflammatory agents and...
US4535186 (A), filed
Wed Oct 26 00:00:00 CDT 1983
, published
Tue Aug 13 00:00:00 CDT 1985
- AMERICAN HOME PROD
This invention provides a group of hydroxycycloalkanephenethyl amine antidepressant derivatives of the following structural formula: IMAGE in which A is a moiety of the formula IMAGE where the dotted line represents optional unsaturation; R1 is hydrogen...
US6448396 (B2), filed
Wed Sep 23 00:00:00 CDT 1998
, published
Tue Sep 10 00:00:00 CDT 2002
- LILLY CO ELI
The present invention provides a process of preparing a compound of the formula IVwherein:R1 and R2 are each individually -(C1-C6)alkyl, -(C1-C6)alkoxy or phenyl,R3 is H or -(C1-C6)alkyl,R6 is -NR7R8, morpholin-1-yl, imidazol-1-yl, 4,5-dihydro-1H-imidazol-2-yl...
US6388094 (B1), filed
Mon Nov 01 00:00:00 CST 1999
, published
Tue May 14 00:00:00 CDT 2002
- SEARLE CO
A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
US4335022 (A), filed
Mon Dec 22 00:00:00 CST 1980
, published
Tue Jun 15 00:00:00 CDT 1982
- SHELL OIL CO
A novel siliceous composition prepared by impregnating porous silica with aluminum hydride and subsequently heating the impregnated silica to a temperature of from about 300 DEG C. to about 900 DEG C. in a non-oxidizing environment. The composition is useful...
US4384882 (A), filed
Fri Mar 05 00:00:00 CST 1982
, published
Tue May 24 00:00:00 CDT 1983
- CIBA GEIGY CORP
Herbicidal and plant growth-regulating pyridiyloxy-phenoxyalkanecarboxylic acid derivatives of the formula IMAGE wherein A is cyano or carboxyl, an ester, thioester or amido radical or the salt of the carboxylic acid with a cation or a quaternary ammonium...
US5883105 (A), filed
Thu Mar 27 00:00:00 CST 1997
, published
Tue Mar 16 00:00:00 CST 1999
- MERCK CO INC
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention...
US6716844 (B2), filed
Mon Dec 03 00:00:00 CST 2001
, published
Tue Apr 06 00:00:00 CDT 2004
- PHARMACIA CORP
An aromatic sulfonyl aipha-hydroxy hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid compound in...
US7005450 (B2), filed
Wed Apr 07 00:00:00 CDT 2004
, published
Tue Feb 28 00:00:00 CST 2006
- PHARMACIA CORP
The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
US4137070 (A), filed
Thu Dec 09 00:00:00 CST 1971
, published
Tue Jan 30 00:00:00 CST 1979
- STAUFFER CHEMICAL CO
Herbicidal compositions consisting of an active herbicidal compound and an antidote therefor and the methods of use of the herbicide composition are described herein. The antidote compound corresponds to the formula: IMAGE wherein R can be selected from...
US4362547 (A), filed
Fri Jan 09 00:00:00 CST 1981
, published
Tue Dec 07 00:00:00 CST 1982
- MONSANTO CO
Imides derived from 2-thioxo-3-benzothiazoline acetic and propionic have been found to be effective as herbicides and plant growth regulants.
US4542609 (A), filed
Thu Sep 13 00:00:00 CDT 1984
, published
Tue Sep 24 00:00:00 CDT 1985
- MONSANTO CO
Derivatives of 2-imino-1,3-dithiolane, 1,3-dithiole, 1,3-dithiane, 1,3-dithietane and 1,3-oxathiole have been found to reduce herbicidal injury to crop plants due to thiocarbamate and acetanilide herbicides.
US4247558 (A), filed
Wed May 02 00:00:00 CDT 1979
, published
Tue Jan 27 00:00:00 CST 1981
- SMITH KLINE FRENCH LAB
US7358254 (B2), filed
Mon Jun 21 00:00:00 CDT 2004
, published
Tue Apr 15 00:00:00 CDT 2008
- HARVARD COLLEGE
A method is provided for treating atherosclerosis and related diseases, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antiatherosclerotic agent, for example, an HMG CoA reductase inhibitor such as pravastatin.
US6667305 (B1), filed
Mon Jan 06 00:00:00 CST 2003
, published
Tue Dec 23 00:00:00 CST 2003
- ATHENA NEUROSCIENCES INC
Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide...
US6387941 (B1), filed
Mon Oct 23 00:00:00 CDT 2000
, published
Tue May 14 00:00:00 CDT 2002
- PFIZER
Compounds of the formulawhere W isn is 0, 1, or 2; m is 0, 1, 2, or 3: Y and G are each independently oxygen or sulfur; Z is -O-, -S-, -NH, or -CH2; R1 is hydrogen, C1 to C8 alkyl, substituted C1 to C8 alkyl substituted with one hydroxy, C3 to C8 alkenyl, C3...
US4376076 (A), filed
Thu May 20 00:00:00 CDT 1982
, published
Tue Mar 08 00:00:00 CST 1983
- PFIZER
Bis-Esters of 1,1-alkanediols with 6-beta(hydroxymethyl)penicillanic acid 1,1-dioxide and 6-betaacylaminopenicillanic acids are useful as antibacterial agents. Intermediates useful for the preparation of these compounds include halomethyl, alkylsulfonyloxymeth...
US6916797 (B2), filed
Fri Aug 30 00:00:00 CDT 2002
, published
Tue Jul 12 00:00:00 CDT 2005
- UCB SA
The invention relates to new alpha-arylethylpiperazine of the formula wherein Z represents 0 or S; n' represents 1 or 2; RSUP2 /SUPrepresents a hydrogen atom or a methyl group; W, ArSUP1 /SUPand ArSUP2 /SUPrepresent various substituents as defined herein; or...
US4411925 (A), filed
Wed Nov 05 00:00:00 CST 1980
, published
Tue Oct 25 00:00:00 CDT 1983
- PFIZER
Amides of L-aspartyl-D-amino acid dipeptides of the formula IMAGE (I) and physiologically acceptable cationic and acid addition salts thereof wherein Ra is methyl, ethyl, n-propyl or isopropyl; R is a branched member selected from the group consisting of...
US6869943 (B2), filed
Thu Aug 21 00:00:00 CDT 2003
, published
Tue Mar 22 00:00:00 CST 2005
- PFIZER
This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I,wherein R1, R2 and R3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of...
US5364866 (A), filed
Fri Oct 30 00:00:00 CST 1992
, published
Tue Nov 15 00:00:00 CST 1994
- HOECHST ROUSSEL PHARMA
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The...
US5986104 (A), filed
Thu Nov 12 00:00:00 CST 1998
, published
Tue Nov 16 00:00:00 CST 1999
- MONSANTO CO
Processes for preparing substituted 3-aryl-5-haloalkyl-pyrazoles and, specifically, for preparing C1-5 alkyl esters of 5-[1-(C1-5 alkyl)-4-halo-5-(C1-3 haloalkyl)-1H-pyrazole-3-yl]-2,4-dihalo-benzoic acids such as isopropyl 5-[4-bromo-1-methyl-5-(trifluorometh...
US7115656 (B2), filed
Tue Feb 17 00:00:00 CST 2004
, published
Tue Oct 03 00:00:00 CDT 2006
- MARS INC
This invention discloses methods of anti-platelet therapy or prophylaxis comprising administering to a subject in need thereof a composition comprising an effective amount of a procyanidin oligomer or a derivative thereof.
US4269775 (A), filed
Fri Aug 24 00:00:00 CDT 1979
, published
Tue May 26 00:00:00 CDT 1981
- CIBA GEIGY CORP
The invention relates to oximes of the formula IMAGE (I) wherein n is 0, 1 or 2 and m is 0 or 1, and wherein Ar is a phenyl radical IMAGE a naphthyl radical substituted by R2 and R3, a 5- to 10-membered heterocyclic radical which contains not more than...
US6797826 (B2), filed
Wed Sep 04 00:00:00 CDT 2002
, published
Tue Sep 28 00:00:00 CDT 2004
- AMR TECHNOLOGY INC
The present invention relates to substantially pure piperidine derivative compounds of the formulae:whereinR1 is hydrogen or hydroxy;R2 is hydrogen;or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2;R3 is -COOH or...
US4332798 (A), filed
Wed Jan 30 00:00:00 CST 1980
, published
Tue Jun 01 00:00:00 CDT 1982
- FUJISAWA PHARMACEUTICAL CO
7-Substituted-3-cephem and cepham-4-carboxylic acids of formula (I) IMAGE (I) wherein R1 is amino or a protected amino, R2 is hydrogen, acyl, aryl which may be substituted with suitable substituent(s), lower alkyl substituted with suitable substituent(s),...
US4826531 (A), filed
Fri Apr 17 00:00:00 CDT 1987
, published
Tue May 02 00:00:00 CDT 1989
- ICI PLC
Acrylic acid derivatives having the formula (I): IMAGE (I) and stereoisomers thereof, wherein W is R1O2C-C=CH-ZR2, R1 and R2 are alkyl or fluoroalkyl groups, and Z is oxygen or sulphur; A, B, D and E are hydrogen, halogen, hydroxy or optionally substituted...
US5089025 (A), filed
Fri Jan 25 00:00:00 CST 1991
, published
Tue Feb 18 00:00:00 CST 1992
- HENKEL KGAA
PCT No. PCT/EP89/00834 Sec. 371 Date Jan. 25, 1991 Sec. 102(e) Date Jan. 25, 1991 PCT Filed Jul. 17, 1989 PCT Pub. No. WO90/01050 PCT Pub. Date Feb. 8, 1990.The invention relates to the use of compounds corresponding to formula (I) IMAGE (1) in which one of...
US6686471 (B2), filed
Thu Jun 05 00:00:00 CDT 2003
, published
Tue Feb 03 00:00:00 CST 2004
- PFIZER
This invention relates to a process for preparing compounds of the Formula I,wherein R1, R2 and Pt are as defined in the specification, which are intermediates in the synthesis of certain growth hormone secretagogue compounds. This invention further relates to...
US4282233 (A), filed
Thu Jun 19 00:00:00 CDT 1980
, published
Tue Aug 04 00:00:00 CDT 1981
- SCHERING CORP
11-(4-Piperidylidene)-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridines and their 5,6-dihydro derivatives are disclosed. The compounds are useful as antihistamines with little or no sedative effects.
US4282233 (B1), filed
Thu Jun 19 00:00:00 CDT 1980
, published
Tue Sep 05 00:00:00 CDT 2000
- SCHERING CORP
US5196141 (A), filed
Mon Oct 22 00:00:00 CDT 1990
, published
Tue Mar 23 00:00:00 CST 1993
- MERCK PATENT GMBH
PCT No. PCT/EP90/01351 Sec. 371 Date Oct. 22, 1990 Sec. 102(e) Date Oct. 22, 1990 PCT Filed Aug. 17, 1990 PCT Pub. No. WO91/02722 PCT Pub. Date Mar. 7, 1991.The invention relates to 5-oxy-2-phenylpyridines of the formula I IMAGE I in which m and n,...
US4321082 (A), filed
Mon Jul 21 00:00:00 CDT 1980
, published
Tue Mar 23 00:00:00 CST 1982
- MONSANTO CO
Derivatives of 2-imino-1,3-dithiolane, 1,3-dithiole, 1,3-dithiane, 1,3-dithietane and 1,3-oxathiole have been found to reduce herbicidal injury to crop plants due to thiocarbamate and acetanilide herbicides.
US4383031 (A), filed
Thu Jun 21 00:00:00 CDT 1979
, published
Tue May 10 00:00:00 CDT 1983
- MILES LAB
A homogeneous specific binding assay which employs a substance having reactant activity, i.e., a reactant, in a chemiluminescent reaction as a labeling substance in the detection of a ligand in a liquid medium. The assay employs a conjugate formed of a...
US4801600 (A), filed
Fri Oct 09 00:00:00 CDT 1987
, published
Tue Jan 31 00:00:00 CST 1989
- DU PONT
US4894456 (A), filed
Tue Mar 31 00:00:00 CST 1987
, published
Tue Jan 16 00:00:00 CST 1990
- RES TRIANGLE INST
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show...
US5466823 (A), filed
Tue Nov 30 00:00:00 CST 1993
, published
Tue Nov 14 00:00:00 CST 1995
- SEARLE CO
A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: IMAGE (I) or a pharmaceutically-acceptable salt thereof.
US6656954 (B2), filed
Thu Nov 29 00:00:00 CST 2001
, published
Tue Dec 02 00:00:00 CST 2003
- PHARMACIA CORP
A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl divalent aromatic or heteroaromat...
US5939557 (A), filed
Tue Mar 25 00:00:00 CST 1997
, published
Tue Aug 17 00:00:00 CDT 1999
- MERCK CO INC
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention...
US6303238 (B1), filed
Mon Dec 01 00:00:00 CST 1997
, published
Tue Oct 16 00:00:00 CDT 2001
- UNIV PRINCETON
Organic light emitting devices are disclosed which are comprised of a heterostructure for producing electroluminescence wherein the heterostructure is comprised of an emissive layer containing a phosphorescent dopant compound. For example, the phosphorescent...
US6586603 (B1), filed
Mon Oct 21 00:00:00 CDT 2002
, published
Tue Jul 01 00:00:00 CDT 2003
- SEARLE CO
A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II:wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycarbonyl...
US6048977 (A), filed
Thu Apr 06 00:00:00 CDT 1995
, published
Tue Apr 11 00:00:00 CDT 2000
- SMITHKLINE BEECHAM PLC
A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts...
US6048977 (C1), filed
Thu Apr 06 00:00:00 CDT 1995
, published
Tue Oct 16 00:00:00 CDT 2001
- SMITHKLINE BEECHAM PLC
US6867305 (B2), filed
Thu Mar 01 00:00:00 CST 2001
, published
Tue Mar 15 00:00:00 CST 2005
- SLOAN KETTERING INST CANCER
The present invention provides convergent processes for preparing epothilones, desoxyepothilones, and analogues thereof. The present invention further provides novel compositions and methods for the treatment of cancer and additionally provides methods for the...
US7183408 (B2), filed
Tue Apr 19 00:00:00 CDT 2005
, published
Tue Feb 27 00:00:00 CST 2007
- WARNER LAMBERT CO
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in...
US6603002 (B2), filed
Wed Jul 31 00:00:00 CDT 2002
, published
Tue Aug 05 00:00:00 CDT 2003
- PFIZER
This invention relates to a process for preparing compounds of the Formula I,wherein R1, R2 and Pt are as defined in the specification, which are intermediates in the synthesis of certain growth hormone secretagogue compounds. This invention further relates to...
US5874452 (A), filed
Thu Mar 27 00:00:00 CST 1997
, published
Tue Feb 23 00:00:00 CST 1999
- MERCK CO INC
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention...
US6620835 (B2), filed
Tue Jun 04 00:00:00 CDT 2002
, published
Tue Sep 16 00:00:00 CDT 2003
- WARNER LAMBERT CO
The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula IMore particularly, the present invention relates to a method of treating diseases in which...
US6344463 (B1), filed
Fri Jul 07 00:00:00 CDT 2000
, published
Tue Feb 05 00:00:00 CST 2002
- ALLERGAN SALES INC
Compounds of the formulawhere R1 and R2, independently are alkyl groups having 2 to 8 carbons; R3 is hydrogen or lower alkyl; X is S, O or N-R4 where R4 is hydrogen or lower alkyl; Y is phenyl or pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, and...
US6921826 (B2), filed
Wed Oct 29 00:00:00 CST 2003
, published
Tue Jul 26 00:00:00 CDT 2005
- 3M INNOVATIVE PROPERTIES CO
Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are...
US5281628 (A), filed
Fri Oct 04 00:00:00 CDT 1991
, published
Tue Jan 25 00:00:00 CST 1994
- AMERICAN CYANAMID CO
9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel...
US5420148 (A), filed
Tue Jun 21 00:00:00 CDT 1994
, published
Tue May 30 00:00:00 CDT 1995
- BAYER AG
A novel fungicidal composition comprising a fungicidally effective amount of a combination consisting of the known 2-cyanobenz imidazole of the formula IMAGE (I) in which A has the meanings given in the description and at least one other known fungicidal...
US5618969 (A), filed
Thu Oct 19 00:00:00 CDT 1995
, published
Tue Apr 08 00:00:00 CDT 1997
- EISAI CO LTD
The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II...
US4980095 (A), filed
Mon Jun 01 00:00:00 CDT 1987
, published
Tue Dec 25 00:00:00 CST 1990
- WARNER LAMBERT CO
Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic...
US6297380 (B1), filed
Fri Nov 12 00:00:00 CST 1999
, published
Tue Oct 02 00:00:00 CDT 2001
- PFIZER
This invention relates to a process for preparing compounds of the Formula I,wherein R1, R2 and Pt are as defined in the specification, which are intermediates in the synthesis of certain growth hormone secretagogue compounds. This invention further relates to...
US6545017 (B1), filed
Fri Jun 07 00:00:00 CDT 2002
, published
Tue Apr 08 00:00:00 CDT 2003
- 3M INNOVATIVE PROPERTIES CO
Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of...
US6515135 (B2), filed
Thu Jun 28 00:00:00 CDT 2001
, published
Tue Feb 04 00:00:00 CST 2003
- UPJOHN CO
The present invention provides for aminoaryl oxazolidinone N-oxide compounds of Formula Iwherein the variables are as defined herein. These compounds are exceedingly water soluble which is useful in preparing pharmaceutical formulations of these compounds....
US4465618 (A), filed
Wed Feb 24 00:00:00 CST 1982
, published
Tue Aug 14 00:00:00 CDT 1984
- FIRMENICH CIE
New spiranic compound, viz. 6-ethyl-2,10,10-trimethyl-1-oxaspiro[4.5]deca-3,6-diene, for use therefor as perfume or flavor-modifying ingredient.
US7265132 (B2), filed
Thu Sep 09 00:00:00 CDT 2004
, published
Tue Sep 04 00:00:00 CDT 2007
- BOEHRINGER INGELHEIM PHARMA
Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds
US4394506 (A), filed
Fri Nov 30 00:00:00 CST 1979
, published
Tue Jul 19 00:00:00 CDT 1983
- DU PONT
N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted in the 2-position by a carboxy radical, ester, thioester, or amide thereof; e.g. N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-2-methoxycarbonylbenzene sulfonamide or...
US4329167 (A), filed
Mon Apr 14 00:00:00 CST 1980
, published
Tue May 11 00:00:00 CDT 1982
- CIBA GEIGY CORP
Herbicidal and plant growth-regulating pyridyloxy-phenoxyalkanecarboxylic acid derivatives of the formula IMAGE wherein A is cyano or carboxyl, an ester, thioester or amido radical or the salt of the carboxylic acid with a cation or a quaternary ammonium...
US4235783 (A), filed
Fri Sep 07 00:00:00 CDT 1979
, published
Tue Nov 25 00:00:00 CST 1980
- UPJOHN CO
The present invention relates to novel trans-2,3,4,5-tetradehydro-9-deoxy-5,9a-epoxy-PGF1 amides, which are useful for inducing a variety of prostacyclin-like pharmacological effects. Accordingly, these compounds are useful pharmacological agents for the same...
US5304653 (A), filed
Tue Oct 06 00:00:00 CDT 1992
, published
Tue Apr 19 00:00:00 CDT 1994
- ROUSSEL UCLAF
A compound of the formula IMAGE I wherein Ar is phenyl optionally substituted with at least one member of the group consisting of halogen, methylenedioxy, phenyl, phenoxy, -CF3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, Z is selected from the...
US6410739 (B1), filed
Mon Oct 23 00:00:00 CDT 2000
, published
Tue Jun 25 00:00:00 CDT 2002
- PFIZER
Compounds of the formulawhere W isare particularly useful in treating migraine and other disorders, such as depression, anxiety, eating disorders, obesity, drug abuse, cluster headache, pain and chronic paroxysmal hemicrania and headache associated with...
US4849528 (A), filed
Wed Jun 10 00:00:00 CDT 1987
, published
Tue Jul 18 00:00:00 CDT 1989
- LONZA AG
4-Benzyloxy-3-pyrrolin-2-on-1-yl acetamide is an advantageous intermediate product for the production of pharmaceutically effective 4-hydroxypyrrolidin-2-1-yl acetamide. Processes for the production of the intermediate product as well as the active substance...
US5688955 (A), filed
Wed Feb 05 00:00:00 CST 1997
, published
Tue Nov 18 00:00:00 CST 1997
- ADOLOR CORP
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, III and IV have the structure: IMAGE (I) IMAGE (II) IMAGE (III) IMAGE (IV) wherein...
US6121458 (A), filed
Thu Nov 12 00:00:00 CST 1998
, published
Tue Sep 19 00:00:00 CDT 2000
- MONSANTO CO
Processes for preparing substituted 3-aryl-5-haloalkyl-pyrazoles and, specifically, for preparing C1-5 alkyl esters of 5-[1-(C1-5 alkyl)-4-halo-5-(C1-3 haloalkyl)-1H-pyrazole-3-yl]-2,4-dihalo-benzoic acids such as isopropyl 5-[4-bromo-1-methyl-5-(trifluorometh...
