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US6048524 (A), filed
May 22, 1995
, published
Apr 11, 2000
- TRANSKARYOTIC THERAPIES INC
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) which encodes erythropoietin or an insulinotropin [e.g., derivatives of...
US6355241 (B1), filed
Oct 19, 1999
, published
Mar 12, 2002
- TRANSKARYOTIC THERAPIES INC
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) which encodes erythropoietin or an insulinotropin [e.g., derivatives of...
US6846676 (B2), filed
Jun 08, 1999
, published
Jan 25, 2005
- TRANSKARYOTIC THERAPIES INC
The invention provides primary and secondary cells that are transfected with a nucleic acid molecule that encodes erythropoietin, clonal or heterogenous strains of such cells, and methods of producing these cell strains.
US5994127 (A), filed
Nov 04, 1994
, published
Nov 30, 1999
- TRANSKARYOTIC THERAPIES INC
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) which encodes erythropoietin or an insulinotropin [e.g., derivatives of...
US6531124 (B1), filed
Aug 16, 1999
, published
Mar 11, 2003
- TRANSKARYOTIC THERAPIES INC
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) that encodes erythropoietin or an insulinotropin (e.g., derivatives of...
US6670178 (B1), filed
Apr 19, 2000
, published
Dec 30, 2003
- TRANSKARYOTIC THERAPIES INC
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) that encodes erythropoietin or an insulinotropin (e.g., derivatives of...
US6692737 (B1), filed
Apr 13, 2000
, published
Feb 17, 2004
- TRANSKARYOTIC THERAPIES INC
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) which encodes a desired (e.g., a therapeutic) product or is itself a desired...
US6303379 (B1), filed
Jul 16, 1999
, published
Oct 16, 2001
- TRANSKARYOTIC THERAPIES INC
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) which encodes a desired (e.g., a therapeutic) product or is itself a desired...
US6054288 (A), filed
May 18, 1995
, published
Apr 25, 2000
- TRANSKARYOTIC THERAPIES INC
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) which encodes a desired (e.g., a therapeutic) product or is itself a desired...
US6048729 (A), filed
Nov 04, 1994
, published
Apr 11, 2000
- TRANSKARYOTIC THERAPIES INC
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) which encodes a desired (e.g., a therapeutic) product or is itself a desired...
US6537542 (B1), filed
Apr 14, 2000
, published
Mar 25, 2003
- TRANSKARYOTIC THERAPIES INC
The present invention relates to a method of gene or DNA targeting in cells of vertebrate, particularly mammalian, origin. That is, it relates to a method of introducing DNA into primary or secondary cells of vertebrate origin through homologous recombination...
US6214622 (B1), filed
May 18, 1995
, published
Apr 10, 2001
- TRANSKARYOTIC THERAPIES INC
The present invention relates to a method of gene or DNA targeting in cells of vertebrate, particularly mammalian, origin. That is, it relates to a method of introducing DNA into primary or secondary cells of vertebrate origin through homologous recombination...
US6187305 (B1), filed
May 18, 1995
, published
Feb 13, 2001
- TRANSKARYOTIC THERAPIES INC
The present invention relates to a method of gene or DNA targeting in cells of vertebrate, particularly mammalian, origin. That is, it relates to a method of introducing DNA into primary or secondary cells of vertebrate origin through homologous recombination...
US6270989 (B1), filed
Mar 17, 1995
, published
Aug 07, 2001
- TRANSKARYOTIC THERAPIES INC
The invention relates to novel human DNA sequences, targeting constructs, and methods for producing novel genes encoding thrombopoietin, DNase I, and beta-interferon by homologous recombination. The targeting constructs comprise at least: a) a targeting...
US6063630 (A), filed
Apr 20, 1994
, published
May 16, 2000
- TRANSKARYOTIC THERAPIES INC
The present invention relates to a method of gene or DNA targeting in cells of vertebrate, particularly mammalian, origin. That is, it relates to a method of introducing DNA into primary or secondary cells of vertebrate origin through homologous recombination...