Patents
Patent data provided by The
European Patent Office
and updated through early 2009. Full text patent data loaded weekly coming soon.
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USH2191 (H1), filed
Aug 08, 2001
, published
Jun 05, 2007
- SNP CONSORTIUM
The invention relates to the role of genes in human diseases. More particularly, the invention relates to compositions and methods for identifying genes that are involved in human disease conditions. The invention provides identification and mapping of a very...
US3930956 (A), filed
Oct 29, 1973
, published
Jan 06, 1976
- UNIV MICHIGAN
US4257774 (A), filed
Jul 16, 1979
, published
Mar 24, 1981
- MELOY LAB
A novel method for the detection, screening, the quantitation of compounds that interact with nucleic acids (DNA or RNA) is provided. The basis for this method is the inhibition of acridine orange binding to the nucleic acid. Measurement of binding inhibition...
US4455370 (A), filed
Mar 07, 1983
, published
Jun 19, 1984
- DU PONT
Microporous nylon films used as transfer membranes for nucleic acids, proteins, bacteria and viruses.
US4465769 (A), filed
Dec 11, 1981
, published
Aug 14, 1984
- US HEALTH
A non-transformed cell line is produced by treating BALB/c derived 10E2 cells with 5-bromodeoxyuridine and 5-iodo-2'-deoxyuridine to produce thymidine kinaseless cells which upon multiple cloning show a flat epitheloid appearance indicative of their non-transf...
US4666828 (A), filed
Aug 15, 1984
, published
May 19, 1987
- GEN HOSPITAL CORP
A method for detecting the presence of the gene for Huntington's disease in a subject which comprises analyzing the human chromosome 4 of the subject for a DNA polymorphism, preferably a restriction fragment length polymorphism (RFLP), linked to Huntington's...
US4675283 (A), filed
Jul 19, 1984
, published
Jun 23, 1987
- MASSACHUSETTS INST TECHNOLOGY
A novel method for detecting and isolating DNA sequences commonly held by different DNA preparations or repeated or amplified within a complex genome has been provided. The DNA preparations of interest are digested with the same restriction enzyme and a...
US4725536 (A), filed
Sep 19, 1985
, published
Feb 16, 1988
- GENETICS INST
Reagent complexes containing a probe polynucleotide with at least two target binding regions. A labeled polynucleotide is bound to at least a portion of each target binding region. In one method, sample nucleic acid displaces labeled polynucleotide from one...
US4725537 (A), filed
Sep 19, 1985
, published
Feb 16, 1988
- GENETICS INST
A target nucleotide sequence having a half-restriction site is determined in the nucleic acid of a biological sample. It is contacted with a reagent complex of: (i) a labeled probe polynucleotide containing a target binding region which is substantially...
US4775619 (A), filed
Oct 16, 1984
, published
Oct 04, 1988
- CHIRON CORP
Methods for diagnosis employing polynucleotides having oligonucleotide sequences substantially homologous to a sequence of interest, where the presence or absence of hybridization at a predetermined stringency provides for the release of a label from a...
US4775631 (A), filed
Jul 26, 1985
, published
Oct 04, 1988
- JANSSEN PHARMACEUITICA N V
A method of detecting and localizing nucleic acids on polyamide supports which comprises contacting said supports with a suspension of colloidal metal particles whereupon the metal particles bind to the polyamide support and form a colored background against...
US4775745 (A), filed
Dec 08, 1986
, published
Oct 04, 1988
- NAT DISTILLERS CHEM CORP
This invention relates to a diazonium compound of the formula: IMAGE wherein Z is selected from the group consisting of biotin, an antigen, an antibody, a photoreactive group, a fluorescent group and heavy metal-containing compounds; X is an alkylene group...
US4797355 (A), filed
Jun 13, 1985
, published
Jan 10, 1989
- AMGEN INC
A probe is attached to a stock support to which is bound a single-stranded polynucleotide by hybridizing both the probe and the bound polynucleotide to a connecting strand with which they are both complementary and then ligating an end of the bound polynucleot...
US4833084 (A), filed
Aug 26, 1985
, published
May 23, 1989
- MILES INC
A monoclonal antibody specific for DNAxRNA duplexes, particularly DNAxRNA heteropolymer duplexes, characterized by having cross-reactivity for binding to single- or double-stranded DNA or RNA as measured by competitive immunoassay of less than about 1:1000,...
US4870004 (A), filed
Jun 08, 1984
, published
Sep 26, 1989
- AUTOSEQ INC
Apparatus and method of sequencing nucleic acid molecules, including DNA and RNA molecules. Several copies of the molecules are labeled with a radioactive tracer and divided into separate groups. The groups of molecules are then each chemically cleaved to...
