Methods of inhibiting TNFalpha in patients with neoplastic disease - Patent US7214376(B2)
Filed:
Dec 07, 2001
Published:
May 08, 2007
Abstract
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.Applicants
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CENTOCOR INC
Inventors
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LE JUNMING
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GHRAYEB JOHN
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DADDONA PETER
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SIEGEL SCOTT
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VILCEK JAN
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KNIGHT DAVID
Application Number
10010229Priority Claims
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Classification Codes
C07K14/525, C07K16/24, C07K16/30, A61K38/00, A61K39/395, C07K16/28, C07K14/435, C07K16/18
