Methods of treating rheumatoid arthritis by multiple administration of anti-TNF antibodies - Patent US7179466(B2)

Filed: Jun 28, 2002

Published: Feb 20, 2007

Abstract

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-alpha (TNFalpha) and are useful in vivo diagnosis and therapy of a number of TNFalpha-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Applicants

CENTOCOR INC

Inventors

LE JUNMING
GHRAYEB JOHN
DADDONA PETER
SIEGEL SCOTT
VILCEK JAN
KNIGHT DAVID

Application Number

10187121

Priority Claims

US67082791

Family Members

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Classification Codes

C07K14/525, C07K16/24, C07K16/30, A61K38/00, A61K39/395, C07K16/28, C07K14/435, C07K16/18