Peptide inhibiting platelet derived growth factor (PDGF-BB) and fibroblast growth factor (bFGF) activity - Patent US7009036(B2)

Filed: Feb 20, 2002

Published: Mar 07, 2006

Abstract

A novel peptide, derived from the human fibroblast growth factor (bFGF), is identified. The molecule is able to inhibit in vitro the effects of Platelet Derived Growth Factor (PDGF-BB) and basic Fibroblast Growth Factor (bFGF) on primary rat smooth muscle cells (RASMC) and primary bovine endothelial cells (BAEC) The molecule is also able to inhibit in vivo angiogenesis CD1 mice.

Applicants

PROVINCIA ITALIANA DELLA CONGR

Inventors

FACCHIANO FRANCESCO
FACCHIANO ANGELO
FACCHIANO ANTONIO

Application Number

10077746

Priority Claims

ITRM20010088

Family Members

ITRM20010088(D0) - PEPTIDE IN GRADO DI INIBIRE L'ATTIVITA' DEL FATTORE DI CRESCITA DERIVATO DALLE PIASTRINE (PDGF-BB) E DEL FATTORE DI CRESCITA DERIVATO DAI FI

ITRM20010088(A1) - PEPTIDE IN GRADO DI INIBIRE L'ATTIVITA' DEL FATTORE DI CRESCITA DERIVATO DALLE PIASTRINE (PDGF-BB) E DEL FATTORE DI CRESCITA DERIVATO DAI FI

WO02066498(A2) - PEPTIDE INHIBITING PLATELET DERIVED GROWTH FACTOR (PDGF-BB) AND FIBROBLAST GROWTH FACTOR (BFGF) ACTIVITY

US2002119931(A1) - Peptide inhibiting platelet derived growth factor (PDGF-BB) and fibroblast growth factor (bFGF) activity

CA2451089(A1) - PEPTIDE INHIBITING PLATELET DERIVED GROWTH FACTOR (PDGF-BB) AND FIBROBLAST GROWTH FACTOR (BFGF) ACTIVITY

WO02066498(A3) - PEPTIDE INHIBITING PLATELET DERIVED GROWTH FACTOR (PDGF-BB) AND FIBROBLAST GROWTH FACTOR (BFGF) ACTIVITY

EP1414855(A2) - PEPTID ZUR INHIBIERUNG DER AKTIVITÃ„TEN DES VON BLUTPLÃ„TTCHEN ABSTAMMENDEN WACHSTUMSFAKTOR (PDGF-BB) UND DES FIBROBLASTEN-WACHSTUMSFAKTOR (BFGF)

JP2004529103(T) -

US2006014693(A1) - Peptide inhibiting platelet derived growth factor (PDGF-BB) and fibroblast growth factor (bFGF) activity

US7009036(B2) - Peptide inhibiting platelet derived growth factor (PDGF-BB) and fibroblast growth factor (bFGF) activity

AU2002241240(B2) - Peptide inhibiting platelet derived growth factor (PDGF-BB) and fibroblast growth factor (BFGF) activity

Classification Codes

C07K7/06, C07K14/50, A61P35/04, C07K14/435, C07K17/00, A61P9/00, A61P35/00, A61P7/02, A61K38/00, C07K7/00, A61P7/00